Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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Role of tight junctions in hepatitis C virus infection.
Ignacio Benedicto,Francisca Molina-Jiménez,Luisa García-Buey,Virgínia Gondar,Manuel López-Cabrera,Ricardo Moreno-Otero,Pedro L. Majano +6 more
TL;DR: Fondo de Investigacion Sanitaria (PI10/00101); Fundacion Mutua Madrilena; SAF2007-61201; ISCIII/Agencia Lain Entralgo-FIB Hospital de La Princesa
Journal ArticleDOI
Dynamics of particle uptake at cell membranes
TL;DR: This work explores the rich dynamics of uptake for particles of different shapes and extends the model to include stochastic fluctuations, which facilitate uptake and lead to corresponding changes in the phase diagrams.
Journal ArticleDOI
Systemic virotherapy for multiple myeloma
TL;DR: This review provides an analysis of the mechanisms of action of viroTherapy, and summarizes the preclinical and clinical studies of systemic virotherapy developed for the treatment of MM.
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Enhanced Killing of Triple-Negative Breast Cancer Cells by Reassortant Reovirus and Topoisomerase Inhibitors.
Roxana M Rodríguez Stewart,Jameson T.L. Berry,Angela K. Berger,Sung Bo Yoon,Aspen L Hirsch,Jaime A. Guberman,Nirav B. Patel,Gregory K. Tharp,Steven E. Bosinger,Bernardo A. Mainou +9 more
TL;DR: Reovirus infection in the presence of DNA-damaging agents enhances infection and triple-negative breast cancer cell killing by reovirus, and reassortant reoviruses with a novel genetic composition generated by forward genetics in combination with topoisomerase inhibitors more efficiently infect and kill triple- negative breast cancer cells.
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Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Jeffrey M. Bergelson,Jennifer Cunningham,Gustavo Droguett,Evelyn A. Kurt-Jones,Anita Krithivas,Jeong S. Hong,Marshall S. Horwitz,Richard L. Crowell,Robert W. Finberg +8 more
TL;DR: Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.
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The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
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TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
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NF-κB is a target of AKT in anti-apoptotic PDGF signalling
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