Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
Reads0
Chats0
TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
Citations
More filters
Journal ArticleDOI
The tight junction: a multifunctional complex.
TL;DR: A group of integral membrane proteins-occludin, claudins, and junction adhesion molecules-interact with an increasingly complex array of tight junction plaque proteins not only to regulate paracellular solute and water flux but also to integrate such diverse processes as gene transcription, tumor suppression, cell proliferation, and cell polarity.
Journal ArticleDOI
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry.
Matthew J. Evans,Thomas von Hahn,Donna M. Tscherne,Andrew J. Syder,Maryline Panis,Benno Wölk,Theodora Hatziioannou,Jane A. McKeating,Jane A. McKeating,Paul D. Bieniasz,Charles M. Rice +10 more
TL;DR: Using an iterative expression cloning approach, claudin-1 (CLDN1), a tight junction component that is highly expressed in the liver, is identified as essential for HCV entry and a new target for antiviral drug development.
Journal ArticleDOI
Endothelial Cell-to-Cell Junctions: Molecular Organization and Role in Vascular Homeostasis
TL;DR: How the molecular architectures and interactions may represent a mechanistic basis for the function and regulation of junctions, focusing on junction assembly and permeability regulation, is emphasized.
Journal ArticleDOI
Tight junction proteins.
TL;DR: Advances in the knowledge of the molecular structure of TJ support previous physiological models that exhibited TJ as dynamic structures that present distinct permeability and morphological characteristics in different tissues and in response to changing natural, pathological or experimental conditions.
Journal ArticleDOI
Proinflammatory Cytokines Disrupt Epithelial Barrier Function by Apoptosis-Independent Mechanisms
Matthias Bruewer,Andreas Luegering,Andreas Luegering,Torsten Kucharzik,Torsten Kucharzik,Charles A. Parkos,James L. Madara,James L. Madara,Ann M. Hopkins,Asma Nusrat +9 more
TL;DR: These findings for the first time clearly separate the proapoptotic effects of IFN-γ and TNF-α from their abilities to disrupt barrier function.
References
More filters
Journal ArticleDOI
Genetic basis for altered pathogenesis of an immune-selected antigenic variant of reovirus type 3 (Dearing).
TL;DR: It is indicated that a single amino acid change in the T3 hemagglutinin can alter viral growth and tropism within the central nervous system without affecting either its primary replication in the intestine or its pattern of spread to or within thecentral nervous system.
Patent
Control of apoptosis
TL;DR: A method for inhibiting the expression of a selected apoptosis-related gene in a cell, where sites in the selected gene or nucleic acid binding moiety that binds with associated site and the gene are present.
ReportDOI
Regulation of Apoptosis
Sally Kornbluth,Erica K. Evans +1 more
TL;DR: It is found that addition of weel directly to the Xenopus egg extract accelerates apoptosis and is the first study to implicate a pro-apoptotic signaling capacity for the weel tyrosine kinase.
Book ChapterDOI
Electrophoretic Mobility Shift Assay (EMSA).
Smith Mf,Delbary-Gossart S +1 more
TL;DR: Identifying the transcription factors required for the expression of a specific gene can provide a better understanding of the molecular mechanisms involved and suggest new therapies which may specifically target an individual gene or set of genes.
Journal ArticleDOI
Analysis of functional domains on reovirus cell attachment protein σ1 using cloned s1 gene deletion mutants
TL;DR: It was found that mutant sigma 1 forms with segment III or segment IV deleted did not exhibit any detectable L-cell binding activity, whereas mutants with these two segments intact were capable of attaching to L- cell receptors, albeit with reduced efficiencies, which clearly suggest that the host cell binding domain of s Sigma 1 is distinct from its hemagglutination domain.