Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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Reovirus as an experimental therapeutic for brain and leptomeningeal metastases from breast cancer.
Wen Qing Yang,Donna L. Senger,Xueqing Lun,Huong Muzik,Zhong-Qiao Shi,Richard H. Dyck,Kara L. Norman,Penny M. A. Brasher,N B Rewcastle,David George,D A Stewart,Patrick W. K. Lee,Peter A. Forsyth +12 more
TL;DR: In vivo, a single intratumoral administration of reovirus significantly reduced the size of tumors established from two human breast cancer cell lines and significantly prolonged survival in an immunocompetent racine model of leptomeningeal metastases, suggesting that the evaluation ofReovirus as an experimental therapeutic for CNS metastases from breast cancer is warranted.
Journal ArticleDOI
The tight junction protein JAM-A functions as coreceptor for rotavirus entry into MA104 cells.
TL;DR: It is reported that the tight junction proteins JAM-A, occludin, and ZO-1 play an important role during rotavirus entry into MA104 cells.
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The TRiC chaperonin controls reovirus replication through outer-capsid folding.
Jonathan J. Knowlton,Jonathan J. Knowlton,Isabel Fernández de Castro,Alison W. Ashbrook,Daniel R. Gestaut,Paula F. Zamora,Paula F. Zamora,Joshua A. Bauer,J. Craig Forrest,Judith Frydman,Cristina Risco,Terence S. Dermody +11 more
TL;DR: It is discovered that eukaryotic chaperonin T-complex protein-1 (TRiC) ring complex functions in reovirus replication through a mechanism that involves folding the viral σ3 major outer-capsid protein into a form capable of assembling onto virus particles.
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Reciprocal influence of connexins and apical junction proteins on their expressions and functions.
TL;DR: Different types of specialised plasma membrane microdomains, sharing common adaptor molecules, frequently present intermingled relationships where the different proteins co-assemble into macromolecular complexes and their expressions are co-ordinately regulated.
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The alveolar-epithelial barrier: a target for potential therapy.
TL;DR: Novel emerging therapies based on mechanisms that are designed to preserve the function and promote the repair of the alveolar epithelium in patients who have ALI/ARDS are discussed.
References
More filters
Journal ArticleDOI
Selective extraction of polyoma DNA from infected mouse cell cultures.
Journal ArticleDOI
Activators and target genes of Rel/NF-kappaB transcription factors.
TL;DR: It is argued that NF-κB functions more generally as a central regulator of stress responses and pairing stress responsiveness and anti-apoptotic pathways through the use of a common transcription factor may result in increased cell survival following stress insults.
Journal ArticleDOI
Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
Jeffrey M. Bergelson,Jennifer Cunningham,Gustavo Droguett,Evelyn A. Kurt-Jones,Anita Krithivas,Jeong S. Hong,Marshall S. Horwitz,Richard L. Crowell,Robert W. Finberg +8 more
TL;DR: Identification of CAR as a receptor for these two unrelated and structurally distinct viral pathogens is important for understanding viral pathogenesis and has implications for therapeutic gene delivery with adenovirus vectors.
Journal ArticleDOI
The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Arash Grakoui,Shannon K. Bromley,Cenk Sumen,Mark M. Davis,Andrey S. Shaw,Paul M. Allen,Michael L. Dustin +6 more
TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
Journal ArticleDOI
NF-κB is a target of AKT in anti-apoptotic PDGF signalling
TL;DR: A role for NF-κB in growth factor signalling is established and an anti-apoptotic Ras/PI(3)K/Akt/IKK/NF-κBs pathway is defined, thus linking anti-APoptotic signalling with transcription machinery.