Junction Adhesion Molecule Is a Receptor for Reovirus
Erik S. Barton,J. Craig Forrest,Jodi L. Connolly,James D. Chappell,Yuan Liu,Frederick J. Schnell,Asma Nusrat,Charles A. Parkos,Terence S. Dermody +8 more
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TLDR
Reovirus interaction with cell-surface receptors is a critical determinant of both cell-type specific tropism and virus-induced intracellular signaling events that culminate in cell death.About:
This article is published in Cell.The article was published on 2001-02-09 and is currently open access. It has received 627 citations till now. The article focuses on the topics: Tropism & Junctional Adhesion Molecule A.read more
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Journal ArticleDOI
The tight junction: a multifunctional complex.
TL;DR: A group of integral membrane proteins-occludin, claudins, and junction adhesion molecules-interact with an increasingly complex array of tight junction plaque proteins not only to regulate paracellular solute and water flux but also to integrate such diverse processes as gene transcription, tumor suppression, cell proliferation, and cell polarity.
Journal ArticleDOI
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry.
Matthew J. Evans,Thomas von Hahn,Donna M. Tscherne,Andrew J. Syder,Maryline Panis,Benno Wölk,Theodora Hatziioannou,Jane A. McKeating,Jane A. McKeating,Paul D. Bieniasz,Charles M. Rice +10 more
TL;DR: Using an iterative expression cloning approach, claudin-1 (CLDN1), a tight junction component that is highly expressed in the liver, is identified as essential for HCV entry and a new target for antiviral drug development.
Journal ArticleDOI
Endothelial Cell-to-Cell Junctions: Molecular Organization and Role in Vascular Homeostasis
TL;DR: How the molecular architectures and interactions may represent a mechanistic basis for the function and regulation of junctions, focusing on junction assembly and permeability regulation, is emphasized.
Journal ArticleDOI
Tight junction proteins.
TL;DR: Advances in the knowledge of the molecular structure of TJ support previous physiological models that exhibited TJ as dynamic structures that present distinct permeability and morphological characteristics in different tissues and in response to changing natural, pathological or experimental conditions.
Journal ArticleDOI
Proinflammatory Cytokines Disrupt Epithelial Barrier Function by Apoptosis-Independent Mechanisms
Matthias Bruewer,Andreas Luegering,Andreas Luegering,Torsten Kucharzik,Torsten Kucharzik,Charles A. Parkos,James L. Madara,James L. Madara,Ann M. Hopkins,Asma Nusrat +9 more
TL;DR: These findings for the first time clearly separate the proapoptotic effects of IFN-γ and TNF-α from their abilities to disrupt barrier function.
References
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Journal Article
Cell receptors for the mammalian reovirus. I. Syngeneic monoclonal anti-idiotypic antibody identifies a cell surface receptor for reovirus.
John H. Noseworthy,Bernard N. Fields,Marc A. Dichter,C Sobotka,E Pizer,Linda Perry,J T Nepom,Mark I. Greene +7 more
TL;DR: The implications of recognition by neuronal cells of an anti-idiotypic monoclonal antibody directed against the reovirus 3 attachment receptor for the pathogenesis of viral-induced auto-immunity are discussed.
Book ChapterDOI
Electrophoretic mobility shift assay.
TL;DR: This chapter focuses on the practical use of the electrophoretic mobility shift assay (EMSA) in the analysis of specific protein-DNA complex formation and the use of this technique in the characterization of these important interactions.
Journal ArticleDOI
Infectious subvirion particles of reovirus type 3 Dearing exhibit a loss in infectivity and contain a cleaved sigma 1 protein.
TL;DR: Results suggest that cleavage of T3D sigma 1 protein following oral inoculation of newborn mice is at least partly responsible for the decreased growth of T 3D in the intestine and provide additional evidence that T3d sigma1 contains more than a single receptor-binding domain.
Journal ArticleDOI
Rotavirus-Induced Structural and Functional Alterations in Tight Junctions of Polarized Intestinal Caco-2 Cell Monolayers
TL;DR: New insights into rotavirus (RRV) pathogenicity are provided by showing that RRV infection promotes structural and functional injuries localized at the tight junctions (TJ) in the cell-cell junctional complex of cultured polarized human intestinal Caco-2 cells forming monolayers.
Journal ArticleDOI
Antibodies to the junctional adhesion molecule cause disruption of endothelial cells and do not prevent leukocyte influx into the meninges after viral or bacterial infection.
Franziska Lechner,Ulrike Sahrbacher,Tobias Suter,Karl Frei,Manfred Brockhaus,Uwe Koedel,Adriano Fontana +6 more
TL;DR: In the cytokine-induced meningitis model, anti-JAM antibodies failed to prevent leukocyte influx into the central nervous system after infection of mice with Listeria monocytogenes or lymphocytic choriomeningitis virus, and complement-dependent antibody-mediated cytotoxicity was observed in cultured brain endothelial cells treated with anti-G antibodies but not with its Fab fragment.