Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation.
Daoxiang Zhang,Daoxiang Zhang,Yongbin Wang,Zhimin Shi,Jingyi Liu,Pan Sun,Xiaodan Hou,Jian Zhang,Shimin Zhao,Binhua P. Zhou,Jun Mi +10 more
TLDR
It is reported that TGF-β1- or PDGF-induced CAFs switch from oxidative phosphorylation to aerobic glycolysis, and downregulation of isocitrate dehydrogenase 3α (IDH3α) is identified as a marker for this switch.About:
This article is published in Cell Reports.The article was published on 2015-03-03 and is currently open access. It has received 249 citations till now. The article focuses on the topics: Anaerobic glycolysis & Oxidative phosphorylation.read more
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TGF-β signaling in the tumor metabolic microenvironment and targeted therapies
Xueke Shi,Jin Yang,Shuzhi Deng,Hongdan Xu,Deyang Wu,Qingxiang Zeng,Shimeng Wang,T. Hu,Fanglong Wu,Hongmei Zhou +9 more
TL;DR: In this paper , the authors proposed three potential applications of targeting TGFβ-dependent mechanism reprogramming, paving the way for TGF-β-related antitumor therapy from the perspective of metabolism.
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NDUFA4L2 expression predicts poor prognosis in clear cell renal cell carcinoma patients.
TL;DR: It is suggested that ccRCC patients with NDUFA4L2 overexpression may be suitable as a potential therapeutic target for ccR CC patients.
Journal ArticleDOI
The Influence of Breast Tumour-Derived Factors and Wnt Antagonism on the Transformation of Adipose-Derived Mesenchymal Stem Cells into Tumour-Associated Fibroblasts
Malini Visweswaran,Kevin N. Keane,Frank Arfuso,Rodney J. Dilley,Philip Newsholme,Arun Dharmarajan +5 more
TL;DR: The breast tumour milieu may transform ADSCs into a tumour-supportive phenotype, which can be altered by Wnt antagonism, but is independent of metabolic changes.
Journal ArticleDOI
Overexpression of NDUFA4L2 is associated with poor prognosis in patients with colorectal cancer.
TL;DR: Little study has investigated its prognostic value in colorectal cancer (CRC), but immunofluorescence showed a clear colocalization of NDUFA4L2 and cytochrome c in some tumour cells.
Journal ArticleDOI
Cancer-Associated Fibroblasts in the Hypoxic Tumor Microenvironment
TL;DR: The mechanisms underlying the hypoxic regulation of CAFs and how hypoxic CAFs affect cancer development and progression are summarized and the potential therapeutic strategies focused on targeting CAFs in the Hypoxic tumor microenvironment are discussed.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
Journal ArticleDOI
Angiogenesis in cancer and other diseases
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases and integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases, but owing to several unanswered questions, caution is needed.
Journal ArticleDOI
Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
Akira Orimo,Piyush Gupta,Dennis C. Sgroi,Fernando Arenzana-Seisdedos,Thierry Delaunay,Rizwan Naeem,Vincent J. Carey,Andrea L. Richardson,Robert A. Weinberg +8 more
TL;DR: Using a coimplantation tumor xenograft model, it is demonstrated that carcinoma-associated fibroblasts extracted from human breast carcinomas promote the growth of admixed breast carcinoma cells significantly more than do normal mammaries derived from the same patients.
Journal ArticleDOI
Basement membranes: structure, assembly and role in tumour angiogenesis
TL;DR: The basement membrane (BM) as mentioned in this paper is a specialized form of extracellular matrix (ECM) which mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment.
Journal ArticleDOI
Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium.
Aria F. Olumi,Gary D. Grossfeld,Simon W. Hayward,Peter R. Carroll,Thea D. Tlsty,Gerald R. Cunha +5 more
TL;DR: In this paper, the authors demonstrate that fibroblasts associated with carcinomas stimulate tumor progression of initiated nontumorigenic epithelial cells both in an in vivo tissue recombination system and in vitro coculture system.
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