Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation.
Daoxiang Zhang,Daoxiang Zhang,Yongbin Wang,Zhimin Shi,Jingyi Liu,Pan Sun,Xiaodan Hou,Jian Zhang,Shimin Zhao,Binhua P. Zhou,Jun Mi +10 more
TLDR
It is reported that TGF-β1- or PDGF-induced CAFs switch from oxidative phosphorylation to aerobic glycolysis, and downregulation of isocitrate dehydrogenase 3α (IDH3α) is identified as a marker for this switch.About:
This article is published in Cell Reports.The article was published on 2015-03-03 and is currently open access. It has received 249 citations till now. The article focuses on the topics: Anaerobic glycolysis & Oxidative phosphorylation.read more
Citations
More filters
Journal ArticleDOI
iTRAQ-based differential proteomic analysis of the brains in a rat model of delayedcarbon monoxide encephalopathy.
TL;DR: A rat model of DEACMP is established, applying isobaric tags for a relative and absolute quantification (iTRAQ)-based proteomics approach to identify differentially expressed proteins in cerebral tissue, and three proteins, Glial fibrillary acidic protein (GFAP), mitochondrial malate dehydrogenase (MDHM), and isocitrate dehydrogenases subunit alpha (IDH3A), were identified as playing important roles in CNS injuries inDEACMP.
Posted ContentDOI
The Pancreatic Tumor Microenvironment Compensates for Loss of GOT2
Samuel A. Kerk,Lin Lin,Amy L. Myers,Yaqing Zhang,Jennifer A. Jiménez,Peter Sajjakulnukit,Barbara S. Nelson,Brandon Chen,Anthony Robinson,Galloway Thurston,Samantha Kemp,Nina Steele,Megan T. Hoffman,Hui-Ju Wen,Daniel Long,Sarah E. Ackenhusen,Johanna Ramos,Xiaohua Gao,Li Zhang,Anthony Andren,Zeribe C. Nwosu,Stefanie Galbán,Christopher J. Halbrook,David B. Lombard,David Piwnica-Worms,Haoqiang Ying,Howard C. Crawford,Marina Pasca di Magliano,Yatrik M. Shah,Costas A. Lyssiotis +29 more
TL;DR: In this paper, the authors demonstrate that the loss of a mitochondrial glutamate-oxaloacetate transaminase 2 (GOT2) disturbs redox homeostasis and halts proliferation of pancreatic ductal adenocarcinoma (PDA) cells in vitro.
Journal ArticleDOI
Extracellular Vesicle-Mediated Mitochondrial Reprogramming in Cancer
TL;DR: This review explores the different EV-mediated mitochondrial reprogramming mechanisms supporting cancer survival and progression and introduces the most characteristic changes that the EV-biogenesis machinery and mitochondria undergo in the context of cancer.
Journal ArticleDOI
Effect of IDH3a on glucose uptake in lung adenocarcinoma: A pilot study based on [18 F]FDG.
TL;DR: High expression of IDH3a in lung adenocarcinoma patients is associated with higher glucose uptake, which targets AKT‐GLUT1 pathway to affect glucose uptake and metabolites in lung carcininoma.
Journal ArticleDOI
Loss of a gluconeogenic muscle enzyme contributed to adaptive metabolic traits in hummingbirds
E. Osipova,Rico Barsacchi,Tom Brown,K Sadanandan,Andrea H. Gaede,Amanda Almeida Monte,Julia Jarrells,Claudia Moebius,Martin Pippel,Douglas L. Altshuler,Sylke Winkler,Marc Bickle,Maude W. Baldwin,Michael Hiller +13 more
TL;DR: Osipova et al. as mentioned in this paper found that FBP2 (fructose-bisphosphatase 2) was lost during a time period when hovering flight evolved, leading to an increase in glycolysis, mitochondria production and mitochondrial respiration.
References
More filters
Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
Journal ArticleDOI
Angiogenesis in cancer and other diseases
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases and integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases, but owing to several unanswered questions, caution is needed.
Journal ArticleDOI
Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
Akira Orimo,Piyush Gupta,Dennis C. Sgroi,Fernando Arenzana-Seisdedos,Thierry Delaunay,Rizwan Naeem,Vincent J. Carey,Andrea L. Richardson,Robert A. Weinberg +8 more
TL;DR: Using a coimplantation tumor xenograft model, it is demonstrated that carcinoma-associated fibroblasts extracted from human breast carcinomas promote the growth of admixed breast carcinoma cells significantly more than do normal mammaries derived from the same patients.
Journal ArticleDOI
Basement membranes: structure, assembly and role in tumour angiogenesis
TL;DR: The basement membrane (BM) as mentioned in this paper is a specialized form of extracellular matrix (ECM) which mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment.
Journal ArticleDOI
Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium.
Aria F. Olumi,Gary D. Grossfeld,Simon W. Hayward,Peter R. Carroll,Thea D. Tlsty,Gerald R. Cunha +5 more
TL;DR: In this paper, the authors demonstrate that fibroblasts associated with carcinomas stimulate tumor progression of initiated nontumorigenic epithelial cells both in an in vivo tissue recombination system and in vitro coculture system.
Related Papers (5)
Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.
Berna C. Özdemir,Berna C. Özdemir,Tsvetelina Pentcheva-Hoang,Julienne L. Carstens,Xiaofeng Zheng,Chia Chin Wu,Tyler R. Simpson,Hanane Laklai,Hikaru Sugimoto,Hikaru Sugimoto,Christoph Kahlert,Christoph Kahlert,Sergey V. Novitskiy,Ana De Jesus-Acosta,Padmanee Sharma,Pedram Heidari,Umar Mahmood,Lynda Chin,Harold L. Moses,Valerie M. Weaver,Anirban Maitra,James P. Allison,Valerie S. LeBleu,Valerie S. LeBleu,Raghu Kalluri,Raghu Kalluri +25 more