Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation.
Daoxiang Zhang,Daoxiang Zhang,Yongbin Wang,Zhimin Shi,Jingyi Liu,Pan Sun,Xiaodan Hou,Jian Zhang,Shimin Zhao,Binhua P. Zhou,Jun Mi +10 more
TLDR
It is reported that TGF-β1- or PDGF-induced CAFs switch from oxidative phosphorylation to aerobic glycolysis, and downregulation of isocitrate dehydrogenase 3α (IDH3α) is identified as a marker for this switch.About:
This article is published in Cell Reports.The article was published on 2015-03-03 and is currently open access. It has received 249 citations till now. The article focuses on the topics: Anaerobic glycolysis & Oxidative phosphorylation.read more
Citations
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Metabolite sensing and signaling in cancer
TL;DR: An in depth understanding of metabolite signaling will provide new opportunities for the development of therapeutic interventions that target cancer.
Journal ArticleDOI
Hypoxia-inducible microRNA-488 regulates apoptosis by targeting Bim in osteosarcoma.
TL;DR: The data suggest that miRNA-488 may serve as a predictor of response to chemotherapy and as a therapeutic target in human osteosarcomas.
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Hypoxic tumor microenvironment: Implications for cancer therapy.
Sukanya Roy,Subhashree Kumaravel,Ankith Sharma,Camille L. Duran,Kayla J. Bayless,Sanjukta Chakraborty +5 more
TL;DR: The implications of hypoxia in an inflammatory TME and its impact on the signaling and metabolic pathways regulating growth and progression of cancer, along with changes in lymphangiogenic and angiogenic mechanisms are focused on.
Journal ArticleDOI
The proprotein convertase furin is a pro-oncogenic driver in KRAS and BRAF driven colorectal cancer.
Zongsheng He,Lieven Thorrez,Geraldine Siegfried,Sandra Meulemans,Serge Evrard,Sabine Tejpar,Abdel-Majid Khatib,John W.M. Creemers +7 more
TL;DR: It is shown that genetic inactivation of furin suppresses tumorigenic growth, proliferation, and migration in KRAS or BRAF mutant CRC cell lines but not in wild-type KRAS and BRAF cells.
Journal ArticleDOI
Nutritional Exchanges Within Tumor Microenvironment: Impact for Cancer Aggressiveness.
TL;DR: This review is focused on metabolic remodeling of the different cell populations within tumor microenvironment, dealing with reciprocal re-education through the symbiotic sharing of metabolites, behaving both as nutrients and as transcriptional regulators, describing their impact on tumor growth and metastasis.
References
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Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
Journal ArticleDOI
Angiogenesis in cancer and other diseases
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases and integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases, but owing to several unanswered questions, caution is needed.
Journal ArticleDOI
Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
Akira Orimo,Piyush Gupta,Dennis C. Sgroi,Fernando Arenzana-Seisdedos,Thierry Delaunay,Rizwan Naeem,Vincent J. Carey,Andrea L. Richardson,Robert A. Weinberg +8 more
TL;DR: Using a coimplantation tumor xenograft model, it is demonstrated that carcinoma-associated fibroblasts extracted from human breast carcinomas promote the growth of admixed breast carcinoma cells significantly more than do normal mammaries derived from the same patients.
Journal ArticleDOI
Basement membranes: structure, assembly and role in tumour angiogenesis
TL;DR: The basement membrane (BM) as mentioned in this paper is a specialized form of extracellular matrix (ECM) which mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment.
Journal ArticleDOI
Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium.
Aria F. Olumi,Gary D. Grossfeld,Simon W. Hayward,Peter R. Carroll,Thea D. Tlsty,Gerald R. Cunha +5 more
TL;DR: In this paper, the authors demonstrate that fibroblasts associated with carcinomas stimulate tumor progression of initiated nontumorigenic epithelial cells both in an in vivo tissue recombination system and in vitro coculture system.
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