Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation.
Daoxiang Zhang,Daoxiang Zhang,Yongbin Wang,Zhimin Shi,Jingyi Liu,Pan Sun,Xiaodan Hou,Jian Zhang,Shimin Zhao,Binhua P. Zhou,Jun Mi +10 more
TLDR
It is reported that TGF-β1- or PDGF-induced CAFs switch from oxidative phosphorylation to aerobic glycolysis, and downregulation of isocitrate dehydrogenase 3α (IDH3α) is identified as a marker for this switch.About:
This article is published in Cell Reports.The article was published on 2015-03-03 and is currently open access. It has received 249 citations till now. The article focuses on the topics: Anaerobic glycolysis & Oxidative phosphorylation.read more
Citations
More filters
Journal ArticleDOI
A New Perspective on the Heterogeneity of Cancer Glycolysis
Michael L. Neugent,Justin Goodwin,Ishwarya Sankaranarayanan,Celal Emre Yetkin,Meng-Hsiung Hsieh,Jung Whan Kim +5 more
TL;DR: A new perspective on how aberrantly altered glycolysis in response to oncogenic signaling is further influenced and remodeled by dynamic metabolic interaction with surrounding tumor-associated stromal cells is discussed, which may paint a new picture of metabolic targeting for cancer therapies with a renewed interest in glucose metabolism.
Journal ArticleDOI
Metabolic reprogramming and crosstalk of cancer-related fibroblasts and immune cells in the tumor microenvironment
TL;DR: Current comprehension of metabolic reprogramming of CAFs and immune cells and crosstalk between them that induces immune responses, and their contributions to tumorigenesis and progression are discussed.
Journal ArticleDOI
Heterogeneity of Glucose Transport in Lung Cancer
TL;DR: An overview of different levels of heterogeneity in glucose uptake and utilization in lung cancer, with diagnostic and therapeutic implications is presented.
Journal ArticleDOI
BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling
Lee Shaashua,Aviad Ben-Shmuel,Meirav Pevsner-Fischer,Gil Friedman,Oshrat Levi-Galibov,Subhiksha Nandakumar,Debra Barki,Reinat Nevo,Lauren E. Brown,Wenhan Zhang,Yan Stein,Chen Lior,Han Sang Kim,Linda Bojmar,William R. Jarnagin,Nicolas Lecomte,Shimrit Mayer,Roni Stok,H. Bishara,Rawand Hamodi,Ephrat Levy-Lahad,Talia Golan,John A. Porco,Christine A. Iacobuzio-Donahue,Nikolaus Schultz,David A. Tuveson,David Lyden,David P. Kelsen,Ruth Scherz-Shouval +28 more
TL;DR: In this paper , the stromal landscape of BRCA -mutated and BRCa Wild-type pancreatic ductal adenocarcinoma was analyzed.
Journal ArticleDOI
Unmasking carcinoma-associated fibroblasts: Key transformation player within the tumor microenvironment
Qing Meng,Xin Luo,Jiaxin Chen,Di Wang,Engeng Chen,Wei Zhang,Guolin Zhang,Wei Zhou,Jianbin Xu,Zhangfa Song +9 more
TL;DR: The main transforming cues that contribute to CAF activation are described and the expanding CAF heterogeneity associated with tumor progression in multiple aspects is unveiled, revealing the prospective promising and challenging stroma-targeted anti-tumor strategies.
References
More filters
Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
Journal ArticleDOI
Angiogenesis in cancer and other diseases
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases and integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases, but owing to several unanswered questions, caution is needed.
Journal ArticleDOI
Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
Akira Orimo,Piyush Gupta,Dennis C. Sgroi,Fernando Arenzana-Seisdedos,Thierry Delaunay,Rizwan Naeem,Vincent J. Carey,Andrea L. Richardson,Robert A. Weinberg +8 more
TL;DR: Using a coimplantation tumor xenograft model, it is demonstrated that carcinoma-associated fibroblasts extracted from human breast carcinomas promote the growth of admixed breast carcinoma cells significantly more than do normal mammaries derived from the same patients.
Journal ArticleDOI
Basement membranes: structure, assembly and role in tumour angiogenesis
TL;DR: The basement membrane (BM) as mentioned in this paper is a specialized form of extracellular matrix (ECM) which mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment.
Journal ArticleDOI
Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium.
Aria F. Olumi,Gary D. Grossfeld,Simon W. Hayward,Peter R. Carroll,Thea D. Tlsty,Gerald R. Cunha +5 more
TL;DR: In this paper, the authors demonstrate that fibroblasts associated with carcinomas stimulate tumor progression of initiated nontumorigenic epithelial cells both in an in vivo tissue recombination system and in vitro coculture system.
Related Papers (5)
Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.
Berna C. Özdemir,Berna C. Özdemir,Tsvetelina Pentcheva-Hoang,Julienne L. Carstens,Xiaofeng Zheng,Chia Chin Wu,Tyler R. Simpson,Hanane Laklai,Hikaru Sugimoto,Hikaru Sugimoto,Christoph Kahlert,Christoph Kahlert,Sergey V. Novitskiy,Ana De Jesus-Acosta,Padmanee Sharma,Pedram Heidari,Umar Mahmood,Lynda Chin,Harold L. Moses,Valerie M. Weaver,Anirban Maitra,James P. Allison,Valerie S. LeBleu,Valerie S. LeBleu,Raghu Kalluri,Raghu Kalluri +25 more