Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation.
Daoxiang Zhang,Daoxiang Zhang,Yongbin Wang,Zhimin Shi,Jingyi Liu,Pan Sun,Xiaodan Hou,Jian Zhang,Shimin Zhao,Binhua P. Zhou,Jun Mi +10 more
TLDR
It is reported that TGF-β1- or PDGF-induced CAFs switch from oxidative phosphorylation to aerobic glycolysis, and downregulation of isocitrate dehydrogenase 3α (IDH3α) is identified as a marker for this switch.About:
This article is published in Cell Reports.The article was published on 2015-03-03 and is currently open access. It has received 249 citations till now. The article focuses on the topics: Anaerobic glycolysis & Oxidative phosphorylation.read more
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Metabolic Reprogramming of Colorectal Cancer Cells and the Microenvironment: Implication for Therapy.
TL;DR: In this paper, the dysregulation of metabolic programs, molecular pathways, the tumor microenvironment and the intestinal microbiota in colorectal carcinoma is addressed, and possible therapeutic strategies, including metabolic inhibition and immune therapy in CRC, as well as modulation of the aberrant intestinal microbiota, are discussed.
Journal ArticleDOI
Nutrient Exploitation within the Tumor–Stroma Metabolic Crosstalk
TL;DR: The current knowledge of metabolic reprogramming in cancer, the tumor-stroma metabolic crosstalk, and the available compounds that may be used to effectively target the tumors' metabolic symbiosis are discussed.
Journal ArticleDOI
Cancer-associated fibroblasts enhance tumor 18F-FDG uptake and contribute to the intratumor heterogeneity of PET-CT.
Chengfang Shangguan,Guifang Gan,Jieying Zhang,Jinliang Wu,Ying Miao,Miao Zhang,Biao Li,Jun Mi +7 more
TL;DR: CAFs promote tumor progression and increase SUVmax of 18F-FDG, suggesting CAFs lead to the intratumor heterogeneity of the SUV and the SUVmax is a prognostic marker for cancer patients.
Journal ArticleDOI
Hypoxia-induced microRNA-301b regulates apoptosis by targeting Bim in lung cancer.
TL;DR: The role of miR‐301b in regulating apoptosis in lung cancer is explored and it is shown that high levels of miRNAs associated with tumour progression are associated with cell death.
Journal ArticleDOI
Mitochondrial division inhibitor (mdivi-1) decreases oxidative metabolism in cancer.
Wenting Dai,Guan Wang,Jason Chwa,Myung Eun Oh,Tharindumala Abeywardana,Yanzhong Yang,Qiong A. Wang,Lei Jiang +7 more
TL;DR: In this paper, metabolic isotope tracing was employed to assess mdivi-1 effects in several cancer cell lines, including lung cancer cells and mouse embryonic fibroblasts (MEFs).
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Angiogenesis in cancer and other diseases
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases and integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases, but owing to several unanswered questions, caution is needed.
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Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
Akira Orimo,Piyush Gupta,Dennis C. Sgroi,Fernando Arenzana-Seisdedos,Thierry Delaunay,Rizwan Naeem,Vincent J. Carey,Andrea L. Richardson,Robert A. Weinberg +8 more
TL;DR: Using a coimplantation tumor xenograft model, it is demonstrated that carcinoma-associated fibroblasts extracted from human breast carcinomas promote the growth of admixed breast carcinoma cells significantly more than do normal mammaries derived from the same patients.
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Basement membranes: structure, assembly and role in tumour angiogenesis
TL;DR: The basement membrane (BM) as mentioned in this paper is a specialized form of extracellular matrix (ECM) which mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment.
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Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium.
Aria F. Olumi,Gary D. Grossfeld,Simon W. Hayward,Peter R. Carroll,Thea D. Tlsty,Gerald R. Cunha +5 more
TL;DR: In this paper, the authors demonstrate that fibroblasts associated with carcinomas stimulate tumor progression of initiated nontumorigenic epithelial cells both in an in vivo tissue recombination system and in vitro coculture system.
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