Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation.
Daoxiang Zhang,Daoxiang Zhang,Yongbin Wang,Zhimin Shi,Jingyi Liu,Pan Sun,Xiaodan Hou,Jian Zhang,Shimin Zhao,Binhua P. Zhou,Jun Mi +10 more
TLDR
It is reported that TGF-β1- or PDGF-induced CAFs switch from oxidative phosphorylation to aerobic glycolysis, and downregulation of isocitrate dehydrogenase 3α (IDH3α) is identified as a marker for this switch.About:
This article is published in Cell Reports.The article was published on 2015-03-03 and is currently open access. It has received 249 citations till now. The article focuses on the topics: Anaerobic glycolysis & Oxidative phosphorylation.read more
Citations
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Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy.
Jiaqi Li,Jie Qing Eu,Li Ren Kong,Li Ren Kong,Lingzhi Wang,Yaw Chyn Lim,Yaw Chyn Lim,Boon Cher Goh,Boon Cher Goh,Andrea Li Ann Wong,Andrea Li Ann Wong +10 more
TL;DR: Therapeutic opportunities, which arise from dysregulated metabolism and metabolic crosstalk are discussed, highlighting strategies that may aid in the precision targeting of altered tumour metabolism with a focus on combinatorial therapeutic strategies.
Journal ArticleDOI
Stromal reprogramming: A target for tumor therapy.
TL;DR: This Review has a discussion over CAF reprogramming as a general concept, inducers and outcomes, and suggests potential strategies to combat this key promoter of tumor.
Journal ArticleDOI
Fibroblasts as Modulators of Local and Systemic Cancer Metabolism.
TL;DR: The recent literature supporting an important role for CAFs in regulation of cancer cell metabolism, and relevant pathways that may serve as targets for therapeutic intervention are reviewed.
Journal ArticleDOI
IDH3α regulates one-carbon metabolism in glioblastoma
Jasmine L. May,Foteini Kouri,Lisa A. Hurley,Juan Liu,Serena Tommasini-Ghelfi,Yanrong Ji,Peng Gao,Andrea E. Calvert,Andrew Lee,Navdeep S. Chandel,Ramana V. Davuluri,Craig Horbinski,Jason W. Locasale,Alexander H. Stegh +13 more
TL;DR: It is demonstrated thatIDH3α, a subunit of the IDH3 heterotetramer, is elevated in glioblastoma (GBM) patient samples compared to normal brain tissue and promotes GBM progression in orthotopic glioma mouse models.
Journal ArticleDOI
miRNAs derived from cancer-associated fibroblasts in colorectal cancer.
Amir Savardashtaki,Zahra Shabaninejad,Ahmad Movahedpour,Roxana Sahebnasagh,Hamed Mirzaei,Michael R. Hamblin +5 more
TL;DR: The pathogenic roles of miRNAs and CAFs in CRC are summarized and for first time, themiRNAs derived from CRC-associated CAFs and their roles in CRC pathogenesis are highlighted.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Angiogenesis in cancer and other diseases
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases and integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases, but owing to several unanswered questions, caution is needed.
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Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
Akira Orimo,Piyush Gupta,Dennis C. Sgroi,Fernando Arenzana-Seisdedos,Thierry Delaunay,Rizwan Naeem,Vincent J. Carey,Andrea L. Richardson,Robert A. Weinberg +8 more
TL;DR: Using a coimplantation tumor xenograft model, it is demonstrated that carcinoma-associated fibroblasts extracted from human breast carcinomas promote the growth of admixed breast carcinoma cells significantly more than do normal mammaries derived from the same patients.
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Basement membranes: structure, assembly and role in tumour angiogenesis
TL;DR: The basement membrane (BM) as mentioned in this paper is a specialized form of extracellular matrix (ECM) which mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment.
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Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium.
Aria F. Olumi,Gary D. Grossfeld,Simon W. Hayward,Peter R. Carroll,Thea D. Tlsty,Gerald R. Cunha +5 more
TL;DR: In this paper, the authors demonstrate that fibroblasts associated with carcinomas stimulate tumor progression of initiated nontumorigenic epithelial cells both in an in vivo tissue recombination system and in vitro coculture system.
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