Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation.
Daoxiang Zhang,Daoxiang Zhang,Yongbin Wang,Zhimin Shi,Jingyi Liu,Pan Sun,Xiaodan Hou,Jian Zhang,Shimin Zhao,Binhua P. Zhou,Jun Mi +10 more
TLDR
It is reported that TGF-β1- or PDGF-induced CAFs switch from oxidative phosphorylation to aerobic glycolysis, and downregulation of isocitrate dehydrogenase 3α (IDH3α) is identified as a marker for this switch.About:
This article is published in Cell Reports.The article was published on 2015-03-03 and is currently open access. It has received 249 citations till now. The article focuses on the topics: Anaerobic glycolysis & Oxidative phosphorylation.read more
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Journal ArticleDOI
Metabolic dysfunction and inflammatory disease: the role of stromal fibroblasts.
TL;DR: Recent research on fibroblast metabolism in inflammatory microenvironments is examined, providing insight into the role of fibroblasts and metabolism in mediating inflammatory disease progression namely cancer, arthritis and fibrotic disorders including chronic kidney disease, pulmonary fibrosis, heart disease and liver disease.
Posted ContentDOI
The Pancreatic Tumor Microenvironment Buffers Redox Imbalance Imposed by Disrupted Mitochondrial Metabolism
Samuel A. Kerk,Lin Lin,Amy L. Myers,Brandon Chen,Peter Sajjakulnukit,Anthony Robinson,Galloway Thurston,Barbara S. Nelson,Samantha Kemp,Nina Steele,Megan T. Hoffman,Hui-Ju Wen,Daniel Long,Sarah E. Ackenhusen,Johanna Ramos,Xiaohua Gao,Li Zhang,Anthony Andren,Zeribe C. Nwosu,Stefanie Galbán,Christopher J. Halbrook,David B. Lombard,Haoqiang Ying,Howard C. Crawford,Marina Pasca di Magliano,Yatrik M. Shah,Costas A. Lyssiotis +26 more
TL;DR: This work demonstrates that the loss of mitochondrial glutamate-oxaloacetate transaminase 2 (GOT2), a component in the malate-aspartate shuttle (MAS), disturbs redox homeostasis and halts proliferation of PDA cells in vitro and describes a potential resistance mechanism mediated by metabolic crosstalk within the pancreatic TME.
Journal ArticleDOI
Targeting Tumour-Associated Fibroblasts in Cancers
TL;DR: The therapeutic potential of targeting stromal cells, especially tumour-associated fibroblasts, within the TME as an adjuvant therapy to sensitize immunosuppressive tumours and prevent cancer progression, chemo-resistance and metastasis is discussed.
Journal ArticleDOI
Obesity-Related Fatty Acid and Cholesterol Metabolism in Cancer-Associated Host Cells.
Ying Ye,Xiaoting Sun,Yongtian Lu +2 more
TL;DR: The lipid metabolism associated with obesity and its role in host cells in the tumor microenvironment is summarized and the current understanding of the molecular pathways involved and future perspectives to benefit from this metabolic complexity are discussed.
Book ChapterDOI
MicroRNAs in the Tumor Microenvironment.
TL;DR: The role of miRNAs in the crosstalk between different cell populations found within the TME is summarized, to illustrate how they act on tumorigenesis and the behavior of cells in theTME context is illustrated.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
Journal ArticleDOI
Angiogenesis in cancer and other diseases
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases and integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases, but owing to several unanswered questions, caution is needed.
Journal ArticleDOI
Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
Akira Orimo,Piyush Gupta,Dennis C. Sgroi,Fernando Arenzana-Seisdedos,Thierry Delaunay,Rizwan Naeem,Vincent J. Carey,Andrea L. Richardson,Robert A. Weinberg +8 more
TL;DR: Using a coimplantation tumor xenograft model, it is demonstrated that carcinoma-associated fibroblasts extracted from human breast carcinomas promote the growth of admixed breast carcinoma cells significantly more than do normal mammaries derived from the same patients.
Journal ArticleDOI
Basement membranes: structure, assembly and role in tumour angiogenesis
TL;DR: The basement membrane (BM) as mentioned in this paper is a specialized form of extracellular matrix (ECM) which mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment.
Journal ArticleDOI
Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium.
Aria F. Olumi,Gary D. Grossfeld,Simon W. Hayward,Peter R. Carroll,Thea D. Tlsty,Gerald R. Cunha +5 more
TL;DR: In this paper, the authors demonstrate that fibroblasts associated with carcinomas stimulate tumor progression of initiated nontumorigenic epithelial cells both in an in vivo tissue recombination system and in vitro coculture system.
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Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.
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