Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation.
Daoxiang Zhang,Daoxiang Zhang,Yongbin Wang,Zhimin Shi,Jingyi Liu,Pan Sun,Xiaodan Hou,Jian Zhang,Shimin Zhao,Binhua P. Zhou,Jun Mi +10 more
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TLDR
It is reported that TGF-β1- or PDGF-induced CAFs switch from oxidative phosphorylation to aerobic glycolysis, and downregulation of isocitrate dehydrogenase 3α (IDH3α) is identified as a marker for this switch.About:
This article is published in Cell Reports.The article was published on 2015-03-03 and is currently open access. It has received 249 citations till now. The article focuses on the topics: Anaerobic glycolysis & Oxidative phosphorylation.read more
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Metabolic rewiring in cancer-associated fibroblasts provides a niche for oncogenesis and metastatic dissemination
Jingyi Liu,Jun Mi,Binhua P. Zhou +2 more
TL;DR: This work discusses recent developments delineating the effects of metabolic symbiosis between CAFs and tumor cells on tumor growth, and examines the role of EMT in this relationship.
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Potential Therapies Targeting Metabolic Pathways in Cancer Stem Cells.
Yao An Shen,Chang Cyuan Chen,Bo Jung Chen,Yu Ting Wu,Jiun Ru Juan,Liang Yun Chen,Yueh Chun Teng,Yau Huei Wei +7 more
TL;DR: In this paper, the authors classify and discuss the unique metabolisms that CSCs rely on for energy production and survival, including mitochondrial respiration, glycolysis, glutaminolysis and fatty acid metabolism.
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Signaling pathways in cancer‐associated fibroblasts: recent advances and future perspectives
Zengli Fang,Qingcai Meng,Jin Xu,Wei Wang,Bo Zhang,Jiang-Kun Liu,Chen Liang,Jie Hua,Yingjun Zhao,Xianjun Yu,Si Shi +10 more
TL;DR: A comprehensive understanding of the signaling cascades in CAFs might help us better understand the roles of CAFs and the tumor microenvironment in cancer progression and may facilitate the development of more efficient and safer stroma-targeted cancer therapies as discussed by the authors .
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Activated fibroblasts in cancer: Perspectives and challenges.
TL;DR: In this paper , the important role of CAFs in the tumor microenvironment and the technological advances that made these discoveries possible, and detailed the models that are currently available for CAF investigation.
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A High-Fat Diet Activates the BAs-FXR Axis and Triggers Cancer-Associated Fibroblast Properties in the Colon
TL;DR: In this article , the authors investigated the impact of a high-fat diet (HFD) on the intestinal stem cell (ISC) niche and its association with colorectal cancer and found that HFD-induced colonic CAF-like MSCs play an indispensable role in balancing the properties of CSCs through activation of the BAs-FXR axis.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Angiogenesis in cancer and other diseases
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases and integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases, but owing to several unanswered questions, caution is needed.
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Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
Akira Orimo,Piyush Gupta,Dennis C. Sgroi,Fernando Arenzana-Seisdedos,Thierry Delaunay,Rizwan Naeem,Vincent J. Carey,Andrea L. Richardson,Robert A. Weinberg +8 more
TL;DR: Using a coimplantation tumor xenograft model, it is demonstrated that carcinoma-associated fibroblasts extracted from human breast carcinomas promote the growth of admixed breast carcinoma cells significantly more than do normal mammaries derived from the same patients.
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Basement membranes: structure, assembly and role in tumour angiogenesis
TL;DR: The basement membrane (BM) as mentioned in this paper is a specialized form of extracellular matrix (ECM) which mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment.
Journal ArticleDOI
Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium.
Aria F. Olumi,Gary D. Grossfeld,Simon W. Hayward,Peter R. Carroll,Thea D. Tlsty,Gerald R. Cunha +5 more
TL;DR: In this paper, the authors demonstrate that fibroblasts associated with carcinomas stimulate tumor progression of initiated nontumorigenic epithelial cells both in an in vivo tissue recombination system and in vitro coculture system.
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