Journal ArticleDOI
Nanopore sensors for nucleic acid analysis
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TLDR
This article reviews the use of nanopore technology in DNA sequencing, genetics and medical diagnostics and suggests that nanopore-based sensors could be competitive with other third-generation DNA sequencing technologies.Abstract:
Nanopore analysis is an emerging technique that involves using a voltage to drive molecules through a nanoscale pore in a membrane between two electrolytes, and monitoring how the ionic current through the nanopore changes as single molecules pass through it. This approach allows charged polymers (including single-stranded DNA, double-stranded DNA and RNA) to be analysed with subnanometre resolution and without the need for labels or amplification. Recent advances suggest that nanopore-based sensors could be competitive with other third-generation DNA sequencing technologies, and may be able to rapidly and reliably sequence the human genome for under $1,000. In this article we review the use of nanopore technology in DNA sequencing, genetics and medical diagnostics.read more
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Journal ArticleDOI
Electrically controlled spin reversal and spin polarization of electronic transport in nanoporous graphene nanoribbons
Rui-Song Shen,Yan-Dong Guo,Xiaohong Yan,Hong-Li Zeng,Miao-Shen Liang,Pei Chen,Mou-Shu Yang,Yang Ni +7 more
TL;DR: In this paper, a three-terminal configuration is proposed, which can electronically control the spin polarization of transmission, instead of magnetic methods, by modulating the gate voltage, not only could the transmission be switched between completely spin up and spin down polarized states to realize a dual-spin filter, but also spin polarization could be finely tuned between 100% and -100%.
Journal ArticleDOI
Diamondoid-functionalized nanogaps: from small molecules to electronic biosensing
Frank C. Maier,Chandra Shekar Sarap,Maofeng Dou,Ganesh Sivaraman,Ganesh Sivaraman,Maria Fyta +5 more
TL;DR: The potential of reading-out DNA molecules using functionalized electrodes embedded in nanopores using tiny diamond-like hydrogenated cages, the diamondoids, is discussed here and the relevance of the results in detecting DNA sequences is discussed.
Journal ArticleDOI
Label-Free Identification of Single Mononucleotides by Nanoscale Electrophoresis
Junseo Choi,Zheng Jia,Ramin Riahipour,Collin J. McKinney,Charuni A. Amarasekara,Kumuditha M. Weerakoon-Ratnayake,Steven A. Soper,Sunggook Park +7 more
TL;DR: In this article, a dual nanopore TOF sensor with 0.5, 1, and 5µm column lengths was used to discriminate four 2-deoxyribonucleoside 5'-monophosphates, dNMPs, in a label-free manner by nanoscale electrophoresis.
Journal ArticleDOI
Full Width at Half Maximum of Nanopore Current Blockage Controlled by a Single-Biomolecule Interface
TL;DR: In this article , the authors proposed a new strategy for regulating molecular sensing from the duration of the analyte, which could guide the resolution of heterogeneity analysis using nanopores and established a substantial correlation between fwhm of current blockage and duration.
Journal ArticleDOI
Electrical trapping mechanism of single-microparticles in a pore sensor
TL;DR: In this paper, the influence of particle trajectory to the ionic conductance through a pore was studied, where the optical/electrical simultaneous sensing of electrophoretic capture dynamics of single-particles at a Pore using a microchannel/nanopore system was performed.
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TL;DR: A public database of common variation in the human genome: more than one million single nucleotide polymorphisms for which accurate and complete genotypes have been obtained in 269 DNA samples from four populations, including ten 500-kilobase regions in which essentially all information about common DNA variation has been extracted.
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