Journal ArticleDOI
Nanopore sensors for nucleic acid analysis
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TLDR
This article reviews the use of nanopore technology in DNA sequencing, genetics and medical diagnostics and suggests that nanopore-based sensors could be competitive with other third-generation DNA sequencing technologies.Abstract:
Nanopore analysis is an emerging technique that involves using a voltage to drive molecules through a nanoscale pore in a membrane between two electrolytes, and monitoring how the ionic current through the nanopore changes as single molecules pass through it. This approach allows charged polymers (including single-stranded DNA, double-stranded DNA and RNA) to be analysed with subnanometre resolution and without the need for labels or amplification. Recent advances suggest that nanopore-based sensors could be competitive with other third-generation DNA sequencing technologies, and may be able to rapidly and reliably sequence the human genome for under $1,000. In this article we review the use of nanopore technology in DNA sequencing, genetics and medical diagnostics.read more
Citations
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Journal ArticleDOI
An area-efficient low-noise CMOS DNA detection sensor for multichannel nanopore applications
TL;DR: In this article, an area-efficient low-noise DNA detection sensor is presented for multichannel nanopore applications, using a novel pseudo-resistor technique to drastically reduce the feedback resistor size.
Journal ArticleDOI
Distinct Mechanisms of DNA Sensing Based on N-Doped Carbon Nanotubes with Enhanced Conductance and Chemical Selectivity
TL;DR: The edge-on mode is shown to operate based on a novel molecular sensing mechanism that reflects the chemical connectivity between N-doped CNT caps that can act both as electron donors and electron acceptors and DNA functional groups that include the hyperconjugated thymine methyl group.
Journal ArticleDOI
Biomedical diagnosis perspective of epigenetic detections using alpha-hemolysin nanopore
Yong Wang,Li-Qun Gu +1 more
TL;DR: Several challenges arise in applying nanopore devices to clinical studies, including super low physiological concentrations of biomarkers resulting in low sensitivity, complex biological sample contents resulting in false signals, and fast translocating speed through the pore resulting in poor detections.
Journal ArticleDOI
Nanocatalyst-Assisted Fine Tailoring of Pore Structure in Holey-Graphene for Enhanced Performance in Energy Storage
Dipak Dutta,Jian Yong Jiang,Anif Jamaluddin,Shih Ming He,Yu Han Hung,Fuming Chen,Jeng Kuei Chang,Ching Yuan Su +7 more
TL;DR: The perfect tailoring of HG with optimized porosity allows the achievement of high areal capacitance and excellent cycling stability due to the facile ion- and charge-transport at high mass loaded electrodes, which could open a new avenue for addressing the long-existing issue of practical application of graphene-based energy storage devices.
Journal ArticleDOI
Single Molecule Bioelectronics and Their Application to Amplification-Free Measurement of DNA Lengths.
Osman Gul,Kaitlin M. Pugliese,Yongki Choi,Patrick C. Sims,Deng Pan,Arith J. Rajapakse,Gregory A. Weiss,Philip G. Collins +7 more
TL;DR: The operation of single-enzyme transistors made using single-walled carbon nanotubes is reviewed, revealing new insights into enzyme function and proving the electronic technique to be complementary to other single-molecule methods based on fluorescence.
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TL;DR: A public database of common variation in the human genome: more than one million single nucleotide polymorphisms for which accurate and complete genotypes have been obtained in 269 DNA samples from four populations, including ten 500-kilobase regions in which essentially all information about common DNA variation has been extracted.
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