Journal ArticleDOI
Non-specific low back pain
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Two treatment strategies are currently used, a stepped approach beginning with more simple care that is progressed if the patient does not respond, and the use of simple risk prediction methods to individualise the amount and type of care provided.About:
This article is published in The Lancet.The article was published on 2017-02-18. It has received 1687 citations till now. The article focuses on the topics: Low back pain & Disease burden.read more
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Journal ArticleDOI
Creating a sustainable model of spine care in underserved communities: the World Spine Care (WSC) charity.
Scott Haldeman,Scott Haldeman,Margareta Nordin,Geoff Outerbridge,Eric L. Hurwitz,Maria Hondras,O’Dane Brady,Deborah Kopansky-Giles,Deborah Kopansky-Giles,Timothy Ford,Emre Acaroglu +10 more
Journal ArticleDOI
The Effects of Tai Chi Chuan Versus Core Stability Training on Lower-Limb Neuromuscular Function in Aging Individuals with Non-Specific Chronic Lower Back Pain.
Liye Zou,Yanjie Zhang,Yang Liu,Xiaopei Tian,Tao Xiao,Xiaolei Liu,Albert Yeung,Jing Liu,Xueqiang Wang,Qing Yang +9 more
TL;DR: Chen-style TCC and CST were found to have protective effects on NF in aging individuals with NLBP, while alleviating non-specific chronic pain.
Journal ArticleDOI
Decoding the intervertebral disc: Unravelling the complexities of cell phenotypes and pathways associated with degeneration and mechanotransduction.
TL;DR: Current knowledge and gaps in knowledge are discussed on the developmental origin of the IVD, the phenotype of the distinct cell types found within theIVD tissues, molecular targets in IVD degeneration identified using bioinformatics strategies, and mechanotransduction pathways that influence IVD cell fate and function.
Journal ArticleDOI
Adherence to Back Pain Clinical Practice Guidelines by Brazilian Physical Therapists: A Cross-sectional Study.
Fabrício Soares de Souza,Carlos Emílio Ladeira,Leonardo Oliveira Pena Costa,Leonardo Oliveira Pena Costa +3 more
TL;DR: Brazilian physical therapists are not using the best available evidence in their clinical decision making for patients with low back pain, and wider dissemination of clinical practice guidelines should be urgently undertaken.
Journal ArticleDOI
MiR-499a-5p suppresses apoptosis of human nucleus pulposus cells and degradation of their extracellular matrix by targeting SOX4.
Jingchuan Sun,Bing Zheng,Rong-xin Sun,Yake Meng,Shunmin Wang,Haisong Yang,Yu Chen,Jiangang Shi,Yongfei Guo +8 more
TL;DR: Results indicate that miR-499a-5p may attenuate TNF-α-induced NPC apoptosis and an imbalance between anabolism and catabolism of the ECM by downregulating SOX4.
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TL;DR: In the Global Burden of Disease Study 2013 (GBD 2013) as mentioned in this paper, the authors estimated the quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013.
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CDC Guideline for Prescribing Opioids for Chronic Pain—United States, 2016
TL;DR: This guideline is intended to improve communication about benefits and risks of opioids for chronic pain, improve safety and effectiveness of pain treatment, and reduce risks associated with long-term opioid therapy.
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CDC Guideline for Prescribing Opioids for Chronic Pain - United States, 2016.
TL;DR: This guideline is intended to improve communication between clinicians and patients about the risks and benefits of opioid therapy for chronic pain, improve the safety and effectiveness of pain treatment, and reduce the risks associated with long-term opioid therapy, including opioid use disorder, overdose, and death.
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Grading the severity of chronic pain.
TL;DR: A Guttman scale analysis showed that pain intensity and disability measures formed a reliable hierarchical scale and may be useful when a brief ordinal measure of global pain severity is required.
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Christopher,Liliana G Ciobanu,Massimo Cirillo,Danny Colombara,Cyrus Cooper,Paolo Cortesi,Michael H. Criqui,John A. Crump,Abel Fekadu Dadi,Koustuv Dalal,Lalit Dandona,Lalit Dandona,Rakhi Dandona,Rakhi Dandona,José Neves,Dragos Virgil Davitoiu,Barbora de Courten,Diego De Leo,Barthelemy Kuate Defo,Louisa Degenhardt,Louisa Degenhardt,Selina Deiparine,Robert P. Dellavalle,Robert P. Dellavalle,Kebede Deribe,Don C. Des Jarlais,Subhojit Dey,Samath D Dharmaratne,Samath D Dharmaratne,Preet Kaur Dhillon,Daniel Dicker,Eric L. Ding,Shirin Djalalinia,Huyen Phuc Do,E. Ray Dorsey,Kadine Priscila Bender dos Santos,Dirk Douwes-Schultz,Kerrie E. Doyle,Tim Driscoll,Manisha Dubey,Bruce Bartholow Duncan,Ziad El-Khatib,Jerisha Ellerstrand,Ahmad Ali Enayati,Aman Yesuf Endries,Sergey Petrovich Ermakov,Holly E. Erskine,Babak Eshrati,Sharareh Eskandarieh,Alireza Esteghamati,Kara Estep,Fanuel Belayneh Bekele Fanuel,Carla Sofia e Sa Farinha,André Faro,Farshad Farzadfar,Mir Sohail Fazeli,Valery L. Feigin,Valery L. Feigin,Seyed-Mohammad Fereshtehnejad,Seyed-Mohammad Fereshtehnejad,João C. Fernandes,Alize J. Ferrari,Tesfaye Regassa Feyissa,Irina Filip,Florian Fischer,Christina Fitzmaurice,Abraham D Flaxman,Luisa Sorio Flor,Nataliya Foigt,Kyle J Foreman,Richard C. Franklin,Nancy Fullman,Thomas Fürst,João M. Furtado,Neal D. Futran,Emmanuela Gakidou,Morsaleh Ganji,Alberto L Garcia-Basteiro,Teshome Gebre,Teshome Gebre,Tsegaye Tewelde Gebrehiwot,Ayele Geleto,Ayele Geleto,Bikila Lencha Gemechu,Hailay Abrha Gesesew,Peter W. Gething,Alireza Ghajar,Katherine B Gibney,Paramjit Gill,Richard F. Gillum,Richard F. Gillum,Ibrahim Abdelmageem Mohamed Ginawi,Ababi Zergaw Giref,Melkamu Dedefo Gishu,Giorgia Giussani,William W Godwin,Audra L Gold,Ellen M Goldberg,Philimon Gona,Amador Goodridge,Sameer Vali Gopalani,Atsushi Goto,Alessandra C. Goulart,Max Griswold,Harish Chander Gugnani,Rashmi Gupta,Rajeev Gupta,Tanush Gupta,Vipin Gupta,Nima Hafezi-Nejad,Gessessew Bugssa Hailu,Alemayehu Hailu,Randah R. Hamadeh,Samer Hamidi,Alexis J Handal,Graeme J. Hankey,Graeme J. Hankey,Sarah Wulf Hanson,Yuantao Hao,Hilda L Harb,Habtamu Abera Hareri,Josep Maria Haro,James D. Harvey,Mohammad Sadegh Hassanvand,Rasmus Havmoeller,Caitlin Hawley,Simon I. Hay,Roderick J. Hay,Nathaniel J Henry,Ileana Heredia-Pi,Julio C. Montañez Hernandez,Pouria Heydarpour,Hans W. Hoek,Howard J. Hoffman,Nobuyuki Horita,H. Dean Hosgood,Sorin Hostiuc,Peter J. Hotez,Damian G Hoy,Aung Soe Htet,Guoqing Hu,Hsiang Huang,Chantal Huynh,Kim Moesgaard Iburg,Ehimario U. Igumbor,Chad Ikeda,Caleb Mackay Salpeter Irvine,Kathryn H. Jacobsen,Nader Jahanmehr,Mihajlo Jakovljevic,Simerjot K Jassal,Mehdi Javanbakht,Sudha P Jayaraman,Panniyammakal Jeemon,Paul N. Jensen,Vivekanand Jha,Vivekanand Jha,Guohong Jiang,Denny John,Sarah Charlotte Johnson,Catherine O. Johnson,Jost B. Jonas,Mikk Jürisson,Zubair Kabir,Rajendra Kadel,Amaha Kahsay,Ritul Kamal,Haidong Kan,Nadim E. Karam,André Karch,Corine Karema,Amir Kasaeian,Getachew Mullu Kassa,Nigussie Assefa Kassaw,Nicholas J Kassebaum,Anshul Kastor,Srinivasa Vittal Katikireddi,Anil Kaul,Norito Kawakami,Peter Njenga Keiyoro,Andre Pascal Kengne,Andre Keren,Yousef Khader,Ibrahim A Khalil,Ejaz Ahmad Khan,Young-Ho Khang,Ardeshir Khosravi,Jagdish Khubchandani,Aliasghar Ahmad Kiadaliri,Christian Kieling,Yun Jin Kim,Daniel Kim,Pauline Kim,Ruth W Kimokoti,Yohannes Kinfu,Adnan Kisa,Adnan Kisa,Katarzyna Kissimova-Skarbek,Mika Kivimäki,Ann Kristin Knudsen,Yoshihiro Kokubo,Dhaval Kolte,Jacek A Kopec,Soewarta Kosen,Parvaiz A Koul,Ai Koyanagi,Michael Kravchenko,Sanjay Krishnaswami,Kristopher J Krohn,G Anil Kumar,Pushpendra Kumar,Sanjiv Kumar,Hmwe H Kyu,Dharmesh Kumar Lal,Ratilal Lalloo,Nkurunziza Lambert,Qing Lan,Anders Larsson,Pablo M Lavados,Janet L Leasher,Paul H. Lee,Jong-Tae Lee,James Leigh,Cheru Tesema Leshargie,Janni Leung,Ricky Leung,Miriam Levi,Yichong Li,Yongmei Li,Darya Li Kappe,Xiaofeng Liang,Misgan Legesse Liben,Stephen S Lim,Shai Linn,Patrick Y Liu,Angela Liu,Shiwei Liu,Yang Liu,Rakesh Lodha,Giancarlo Logroscino,Stephanie J. London,Katharine J Looker,Alan D. Lopez,Alan D. Lopez,Stefan Lorkowski,Paulo A. Lotufo,Nicola Low,Rafael Lozano,Tim C.D. Lucas,Erlyn Rachelle King Macarayan,Hassan Magdy Abd El Razek,Mohammed Magdy Abd El Razek,Mahdi Mahdavi,Marek Majdan,Reza Majdzadeh,Azeem Majeed,Reza Malekzadeh,Reza Malekzadeh,Rajesh Malhotra,Deborah Carvalho Malta,Abdullah Al Mamun,Helena Manguerra,Treh Manhertz,Ana Mantilla,Lorenzo G. Mantovani,Chabila C Mapoma,Laurie B. Marczak,Jose Martinez-Raga,Francisco Rogerlândio Martins-Melo,Ira Martopullo,Winfried März,Manu Raj Mathur,Mohsen Mazidi,Colm McAlinden,Madeline McGaughey,John J. McGrath,John J. McGrath,Martin McKee,Claire McNellan,Suresh Mehata,Man Mohan Mehndiratta,Tefera Chane Mekonnen,Peter Memiah,Ziad A. Memish,Walter Mendoza,Mubarek Abera Mengistie,Desalegn Tadese Mengistu,George A. Mensah,Tuomo J. Meretoja,Atte Meretoja,Haftay Berhane Mezgebe,Renata Micha,Anoushka Millear,Ted R. Miller,Ted R. Miller,Edward J Mills,Mojde Mirarefin,Erkin M. Mirrakhimov,Awoke Misganaw,Shiva Raj Mishra,Philip B. Mitchell,Karzan Abdulmuhsin Mohammad,Alireza Mohammadi,Kedir Endris Mohammed,Shafiu Mohammed,Sanjay K. Mohanty,Ali H. Mokdad,Sarah K Mollenkopf,Lorenzo Monasta,Marcella Montico,Maziar Moradi-Lakeh,Paula Moraga,Rintaro Mori,Chloe Morozoff,Shane D. Morrison,Mark Moses,Cliff Mountjoy-Venning,Kalayu Birhane Mruts,Ulrich O Mueller,Kate Muller,M. E. Murdoch,Gudlavalleti V S Murthy,Kamarul Imran Musa,Jean B. Nachega,Gabriele Nagel,Mohsen Naghavi,Aliya Naheed,Kovin Naidoo,Luigi Naldi,Vinay Nangia,Gopalakrishnan Natarajan,Dumessa Edessa Negasa,Ruxandra Irina Negoi,Ionut Negoi,Charles R. Newton,Charles R. Newton,Josephine W. Ngunjiri,Trang Huyen Nguyen,Quyen Nguyen,Cuong Tat Nguyen,Grant Nguyen,Minh Nguyen,Emma Nichols,Dina Nur Anggraini Ningrum,Dina Nur Anggraini Ningrum,Sandra Nolte,Vuong Minh Nong,Bo Norrving,Jean Jacques Noubiap,Martin O'Donnell,Felix Akpojene Ogbo,In-Hwan Oh,Anselm Okoro,Olanrewaju Oladimeji,Olanrewaju Oladimeji,Tinuke O Olagunju,Andrew T Olagunju,Andrew T Olagunju,Helen E Olsen,Bolajoko O. Olusanya,Jacob Olusegun Olusanya,Kanyin Ong,John Nelson Opio,Eyal Oren,Eyal Oren,Alberto Ortiz,Aaron Osgood-Zimmerman,Majdi Osman,Mayowa O. Owolabi,Mahesh Pa,Rosana E. Pacella,Adrian Pana,Basant Kumar Panda,Christina Papachristou,Christina Papachristou,Eun-Kee Park,Charles D. H. Parry,Mahboubeh Parsaeian,Scott B. Patten,George C Patton,Katherine R. Paulson,Neil Pearce,David M. Pereira,David M. Pereira,Norberto Perico,Konrad Pesudovs,Carrie Beth Peterson,Max Petzold,Michael R. Phillips,David M. Pigott,Julian David Pillay,Christine Pinho,Dietrich Plass,Martin A Pletcher,Svetlana Popova,Richie Poulton,Farshad Pourmalek,Dorairaj Prabhakaran,Noela M Prasad,Narayan Prasad,Carrie Purcell,Mostafa Qorbani,Reginald Quansah,Beatriz Paulina Ayala Quintanilla,Rynaz H S Rabiee,Amir Radfar,Anwar Rafay,Kazem Rahimi,Afarin Rahimi-Movaghar,Vafa Rahimi-Movaghar,Mohammad Hifz Ur Rahman,Mahfuzar Rahman,Rajesh Kumar Rai,Sasa Rajsic,Usha Ram,Chhabi Lal Ranabhat,Zane Rankin,Puja C Rao,P. V. Rao,Salman Rawaf,Sarah E Ray,Robert C. Reiner,Nikolas Reinig,Marissa B Reitsma,Giuseppe Remuzzi,Andre M. N. Renzaho,Serge Resnikoff,Satar Rezaei,Antonio Luiz Pinho Ribeiro,Luca Ronfani,Gholamreza Roshandel,Gholamreza Roshandel,Gregory A. Roth,Ambuj Roy,Enrico Rubagotti,George Mugambage Ruhago,Soheil Saadat,Nafis Sadat,Mahdi Safdarian,Sare Safi,Saeid Safiri,Rajesh Sagar,Ramesh Sahathevan,Joseph Salama,Huda Omer Ba Saleem,Joshua A. Salomon,Sundeep Salvi,Abdallah M. Samy,Juan Sanabria,Juan Sanabria,Damian Santomauro,Itamar S. Santos,João Vasco Santos,Milena M Santric Milicevic,Benn Sartorius,Maheswar Satpathy,Monika Sawhney,Sonia Saxena,Maria Inês Schmidt,Ione Jayce Ceola Schneider,Ben Schöttker,David C. Schwebel,Falk Schwendicke,Soraya Seedat,Sadaf G. Sepanlou,Sadaf G. Sepanlou,Edson Serván-Mori,Tesfaye Setegn,Katya Anne Shackelford,Amira Shaheen,Masood Ali Shaikh,Mansour Shamsipour,Sheikh Mohammed Shariful Islam,Sheikh Mohammed Shariful Islam,Jayendra Sharma,Rajesh Sharma,Jun She,Peilin Shi,Chloe Shields,Girma Temam Shifa,Mika Shigematsu,Yukito Shinohara,Rahman Shiri,Reza Shirkoohi,Shreya Shirude,Kawkab Shishani,Mark G. Shrime,Abla M. Sibai,Inga Dora Sigfusdottir,Inga Dora Sigfusdottir,Diego Augusto Santos Silva,João Pedro Silva,Dayane Gabriele Alves Silveira,Jasvinder A. Singh,Narinder Pal Singh,Dhirendra N Sinha,Eirini Skiadaresi,Vegard Skirbekk,Erica Leigh Slepak,Amber Sligar,David L. Smith,Mari Smith,Badr Hasan Sobaih,Eugene Sobngwi,Reed J D Sorensen,Tatiane Cristina Moraes Sousa,Luciano A. Sposato,Chandrashekhar T Sreeramareddy,Vinay Srinivasan,Jeffrey D. Stanaway,Vasiliki Stathopoulou,Nicholas Steel,Murray B. Stein,Dan J. Stein,Dan J. Stein,Timothy J. Steiner,Timothy J. Steiner,Caitlyn Steiner,S. Steinke,S. Steinke,Mark A. Stokes,Lars Jacob Stovner,Bryan Strub,Michelle L Subart,Mu'awiyyah Babale Sufiyan,Bruno F. Sunguya,Bruno F. Sunguya,Patrick J Sur,Patrick J Sur,Soumya Swaminathan,Bryan L. Sykes,Dillon O Sylte,Rafael Tabarés-Seisdedos,Getachew Redae Taffere,Jukka Takala,Nikhil Tandon,Mohammad Tavakkoli,Nuno Taveira,Hugh R. Taylor,Arash Tehrani-Banihashemi,Tesfalidet Tekelab,Abdullah Sulieman Terkawi,Dawit Jember Tesfaye,Belay Tesssema,Ornwipa Thamsuwan,Katie E Thomas,Amanda G. Thrift,Tenaw Yimer Tiruye,Ruoyan Tobe-Gai,Mette Christophersen Tollånes,Mette Christophersen Tollånes,Marcello Tonelli,Roman Topor-Madry,Roman Topor-Madry,Miguel Tortajada,Mathilde Touvier,Bach Xuan Tran,Suryakant Tripathi,Christopher Troeger,Thomas Truelsen,Derrick Tsoi,Kald Beshir Tuem,Emin Murat Tuzcu,Stefanos Tyrovolas,Kingsley N. Ukwaja,Eduardo A. Undurraga,Eduardo A. Undurraga,Chigozie Jesse Uneke,Rachel L Updike,Olalekan A. Uthman,Benjamin S Chudi Uzochukwu,Job F M van Boven,Santosh Varughese,Tommi Vasankari,S Venkatesh,Narayanaswamy Venketasubramanian,Ramesh Vidavalur,Francesco Saverio Violante,Sergey K Vladimirov,Vasiliy Victorovich Vlassov,Stein Emil Vollset,Fiseha Wadilo,Tolassa Wakayo,Tolassa Wakayo,Yuan-Pang Wang,Marcia R. Weaver,Scott Weichenthal,Elisabete Weiderpass,Robert G. Weintraub,Andrea Werdecker,Ronny Westerman,Harvey Whiteford,Harvey Whiteford,Tissa Wijeratne,Charles Shey Wiysonge,Charles D.A. Wolfe,Charles D.A. Wolfe,Rachel Woodbrook,Anthony D. Woolf,Abdulhalik Workicho,Denis Xavier,Gelin Xu,Simon Yadgir,Mohsen Yaghoubi,Bereket Yakob,Lijing L Yan,Yuichiro Yano,Pengpeng Ye,Hassen Hamid Yimam,Paul S. F. Yip,Naohiro Yonemoto,Seok Jun Yoon,Marcel Yotebieng,Mustafa Z. Younis,Mustafa Z. Younis,Zoubida Zaidi,Maysaa El Sayed Zaki,Elias Asfaw Zegeye,Zerihun Menlkalew Zenebe,Xueying Zhang,Maigeng Zhou,Ben Zipkin,Sanjay Zodpey,Liesl Zühlke,Christopher J L Murray +778 more