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Journal ArticleDOI

Non-specific low back pain

Christopher G. Maher, +3 more
- 18 Feb 2017 - 
- Vol. 389, Iss: 10070, pp 736-747
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TLDR
Two treatment strategies are currently used, a stepped approach beginning with more simple care that is progressed if the patient does not respond, and the use of simple risk prediction methods to individualise the amount and type of care provided.
About: 
This article is published in The Lancet.The article was published on 2017-02-18. It has received 1687 citations till now. The article focuses on the topics: Low back pain & Disease burden.

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Citations
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Small molecule-based treatment approaches for intervertebral disc degeneration: Current options and future directions.

Amir Kamali, +8 more
- 01 Jan 2021 - 
TL;DR: This review pursues to give a comprehensive overview of small molecules, focusing on low molecular weight organic compounds, and their potential utilization in patients with IDD based on recent in vitro, in vivo, and pre-clinical studies.
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Serious Adverse Events and Spinal Manipulative Therapy of the Low Back Region: A Systematic Review of Cases

Jeffrey J. Hebert, +3 more
- 01 Nov 2015 - 
TL;DR: This systematic review describes case details from published articles that describe serious adverse events that have been reported to occur following SMT of the lumbopelvic region.
Journal ArticleDOI

Urolithin A-induced mitophagy suppresses apoptosis and attenuates intervertebral disc degeneration via the AMPK signaling pathway.

Jialiang Lin, +13 more
- 01 Apr 2020 - 
TL;DR: Investigation of the protective effect of UA-induced mitophagy on tert-butyl hydroperoxide-induced apoptosis in nucleus pulposus (NP) cells in vitro and in vivo suggested that UA could be a novel and effective therapeutic strategy for IDD.
Journal ArticleDOI

Lessons learned from intervertebral disc pathophysiology to guide rational design of sequential delivery systems for therapeutic biological factors.

L. Frapin, +5 more
- 01 Sep 2019 - 
TL;DR: It is hypothesize that a sequential delivery strategy that firstly targets the inflammatory, pro-catabolic microenvironment with release of anti-inflammatory or anti- catabolic cytokines, and secondly increases cell density in the less hostile microenvironment by endogenous cell recruitment or exogenous cell injection, would constitute an innovative yet challenging approach to IVD regeneration.
Journal ArticleDOI

Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice.

Shuangfei Ni, +27 more
- 10 Dec 2019 - 
TL;DR: It is shown that osteoclasts create porous area of endplates of the vertebrae and sensory innervation of porous endplates by Netrin-1 release from osteoclast mediates PGE2-induced spinal hypersensitivity in mice, suggesting that osteoclast-initiated porosity of endplate and sensory Innervation are potential therapeutic targets for spinal pain.
References
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Journal ArticleDOI

Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013

Theo Vos, +689 more
- 22 Aug 2015 - 
TL;DR: In the Global Burden of Disease Study 2013 (GBD 2013) as mentioned in this paper, the authors estimated the quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013.
Journal ArticleDOI

CDC Guideline for Prescribing Opioids for Chronic Pain—United States, 2016

Deborah Dowell, +2 more
- 19 Apr 2016 - 
TL;DR: This guideline is intended to improve communication about benefits and risks of opioids for chronic pain, improve safety and effectiveness of pain treatment, and reduce risks associated with long-term opioid therapy.

CDC guideline for prescribing opioids for chronic pain

Tamara M. Haegerich, +2 more
Journal ArticleDOI

CDC Guideline for Prescribing Opioids for Chronic Pain - United States, 2016.

Deborah Dowell, +2 more
TL;DR: This guideline is intended to improve communication between clinicians and patients about the risks and benefits of opioid therapy for chronic pain, improve the safety and effectiveness of pain treatment, and reduce the risks associated with long-term opioid therapy, including opioid use disorder, overdose, and death.
Journal ArticleDOI

Grading the severity of chronic pain.

Michael Von Korff, +3 more
- 01 Aug 1992 - 
TL;DR: A Guttman scale analysis showed that pain intensity and disability measures formed a reliable hierarchical scale and may be useful when a brief ordinal measure of global pain severity is required.
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