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Open AccessJournal ArticleDOI

Optical coherence tomography

TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.
Abstract
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.

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Citations
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Journal ArticleDOI

Signal and resolution enhancements in dual beam optical coherence tomography of the human eye.

TL;DR: In this article, a dual beam version of partial coherence interferometry has been developed for measuring intraocular distances in vivo with a precision on the order of 0.3 to 3 mm.
Journal ArticleDOI

Combinations of techniques in imaging the retina with high resolution.

TL;DR: The review presents the advantages and disadvantages of different possible combinations of OCT and SLO with AO, evaluating criteria in choosing the best OCT method to fit a specific combination of techniques.
Journal ArticleDOI

Optical Coherence Tomography Angiography in Retinal Vascular Diseases and Choroidal Neovascularization

TL;DR: OCT-A provides detailed images of retinal vascular plexuses and quantitative data of pathologic structures and further studies are warranted to define the role of OCT-A in the assessment of retinovascular diseases, with respect to conventional FA and ICG-A.
Journal ArticleDOI

High-flow-velocity and shear-rate imaging by use of color Doppler optical coherence tomography.

TL;DR: This work describes a technique, based on interference signal demodulation at multiple frequencies, to extend the physiological relevance of CDOCT by increasing the dynamic range of measurable velocities to hundreds of millimeters per second.
Patent

Methods and Apparatus for Swept-Source Optical Coherence Tomography

TL;DR: In this paper, a semiconductor optical amplifier (SOA) in a laser ring is chosen to provide low polarization-dependent gain (PDG) and a booster SOA, outside of the ring, is selected to provide high PEG.
References
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Journal ArticleDOI

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TL;DR: A technique in which X-ray transmission readings are taken through the head at a multitude of angles: from these data, absorption values of the material contained within the head are calculated on a computer and presented as a series of pictures of slices of the cranium.
Journal ArticleDOI

Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss.

TL;DR: Nerve fiber layer defects expanded with time, often by the development and coalescence of adjacent areas of damage, and field defects closely corresponded, but nerve fiber layer loss was generally more widespread.
Journal ArticleDOI

Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma.

TL;DR: Estimates suggest that visual field sensitivity in automated testing begins to decline soon after the initial loss of ganglion cells in human eyes with glaucoma, and that this decline is most pronounced in areas that had 0-dB sensitivity in the field test.
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