Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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High-speed optical coherence tomography: basics and applications.
TL;DR: The fundamental limitations and advantages of time-domain and Fourier-domain interferometric detection methods are discussed, and new perspectives on functional imaging with the use of state-of-the-art high-speed OCT technology are demonstrated.
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Adaptive-optics ultrahigh-resolution optical coherence tomography
Boris Hermann,Enrique J. Fernández,Angelika Unterhuber,Harald Sattmann,A. F. Fercher,Wolfgang Drexler,Pedro M. Prieto,Pablo Artal +7 more
TL;DR: In this article, a closed-loop correction of both ocular and system aberrations results in a residual uncorrected wavefront rms of 0.1 µm for a 3.68 mm pupil diameter.
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Evaluation of the glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography
TL;DR: Measurement of RNFL thickness by OCT is useful in detecting early RNFL damage and may provide clinically relevant information in monitoring glaucomatous changes.
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Intraoperative evaluation of breast tumor margins with optical coherence tomography
Freddy T. Nguyen,Adam M. Zysk,Eric J. Chaney,Jan G. Kotynek,Uretz J. Oliphant,Frank J. Bellafiore,Kendrith M. Rowland,Patricia A. Johnson,Stephen A. Boppart +8 more
TL;DR: In this paper, OCT images covering 1 cm 2 regions were acquired from surgical margins of lumpectomy specimens, registered with ink, and correlated with corresponding histologic sections, yielding a sensitivity of 100% and specificity of 82%.
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Reproducibility of Retinal Mapping Using Optical Coherence Tomography
TL;DR: Retinal mapping software of OCT allows reproducible measurement of retinal thickness in both healthy subjects and diabetic patients with macular edema.
References
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