Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Phase-resolved optical frequency domain imaging
TL;DR: It is demonstrated that by correcting for spurious timing-induced phase errors, excellent flow sensitivity can be achieved, limited only by the imaging signal-to-noise ratio.
Journal ArticleDOI
Retinal abnormalities in early Alzheimer's disease.
TL;DR: The results show that AD produces quantifiable abnormalities in the retina, including a specific pattern of RNFL loss, narrow veins, and decreased retinal blood flow in these veins.
Journal ArticleDOI
Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging
Robert J. Zawadzki,Steven M. Jones,Scot S. Olivier,Mingtao Zhao,Bradley A. Bower,Joseph A. Izatt,Stacey S. Choi,Sophie S. Laut,John S. Werner +8 more
TL;DR: A closed-loop adaptive optics system using a Hartmann-Shack wavefront sensor and a bimorph deformable mirror is combined with Fourier-domain optical coherence tomography to image microscopic blood vessels and the cone photoreceptor mosaic.
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Optical coherence tomography angiography
Simon S. Gao,Yali Jia,Miao Zhang,Johnny P. Su,Gangjun Liu,Thomas S. Hwang,Steven T. Bailey,David Huang +7 more
TL;DR: The history of OCTA is covered and its most important clinical applications are surveyed, the salient problems in the interpretation and analysis are described, and recent advances are highlighted.
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Optical coherence tomography to detect and manage retinal disease and glaucoma.
Glenn J. Jaffe,Joseph Caprioli +1 more
TL;DR: OCT is a non-invasive imaging technique that has been used increasingly to diagnose and manage a variety of retinal diseases and glaucoma as discussed by the authors, and it can be used to identify and quantify macular edema, and to measure retinal thickness changes in response to therapy.
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