Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Journal ArticleDOI
Combined scanning optical coherence and two-photon-excited fluorescence microscopy.
TL;DR: Simultaneous imaging of cell nuclei with OCM and TPE is demonstrated in live drosophila embryos and both modes provide rapid en-face imaging with submicrometer resolution.
Journal Article
Submicrometer precision biometry of the anterior segment of the human eye.
Wolfgang Drexler,Angela Baumgartner,Oliver Findl,Christoph K. Hitzenberger,Harald Sattmann,Adolf Friedrich Fercher +5 more
TL;DR: In this article, a modified, more sensitive scanning version of this technique was used to assess the central and peripheral corneal thickness, the anterior chamber depth, and the lens thickness of 20 healthy, emmetropic to moderately myopic eyes.
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Molecular Genetics of Human Retinal Disease
TL;DR: An overview of the basic and clinical biology of the retina is presented, recent progress in understanding the molecular mechanisms of inherited retinal diseases is summarized, and the role that genetics will play in the next phase of research in this area is assessed.
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Superpenetration optical microscopy by iterative multiphoton adaptive compensation technique
TL;DR: It is shown that high quality three-dimensional imaging can be realized at depths beyond the reach of conventional multiphoton microscopy and adaptive optics methods, albeit over restricted distances for a given correction.
Journal ArticleDOI
Optical Doppler tomography
TL;DR: Optical Doppler tomography (ODT) is an imaging modality that takes advantage of the short coherence length of a broadband light sources to perform micrometer-scale, cross-sectional imaging of tissue structure and blood flow dynamics simultaneously as discussed by the authors.
References
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