Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Journal ArticleDOI
Optical methods for distance and displacement measurements
Garry Berkovic,Ehud Shafir +1 more
TL;DR: In this paper, various noncontact optical sensing techniques that can be used to measure distances to objects, and related parameters such as displacements, surface profiles, velocities and vibrations are discussed and compared.
Journal ArticleDOI
Characterization of Epiretinal Membranes Using Optical Coherence Tomography
J. R. Wilkins,Carmen A. Puliafito,Michael R. Hee,Jay S. Duker,Elias Reichel,Jeffery G. Coker,Joel S. Schuman,Eric A. Swanson,James G. Fujimoto +8 more
TL;DR: Optical coherence tomography was able to provide a structural assessment of the macula that was useful in the preoperative and postoperative evaluation of epiretinal membrane surgery and may be useful in characterizing the surgical prognosis of eyes with an epireTinal membrane.
Journal ArticleDOI
The Development, Commercialization, and Impact of Optical Coherence Tomography.
TL;DR: The early history of OCT is reviewed describing how research and development evolves and the important role of multidisciplinary collaboration and expertise, and the concept of an “ecosystem” consisting of research, government funding, collaboration and competition, clinical studies, innovation, entrepreneurship and industry, and impact – all of which must work synergistically.
Journal ArticleDOI
OCT for glaucoma diagnosis, screening and detection of glaucoma progression
TL;DR: A review of the evidence to date suggests that retinal nerve fibre layer remains the dominant parameter for glaucoma diagnosis and detection of progression while initial studies of macular and optic nerve head parameters have shown promising results.
Patent
Grating based phase control optical delay line
TL;DR: In this paper, an apparatus for high speed scanning of an optical delay and its application for performing optical interferometry, ranging, and imaging, including cross sectional imaging using optical coherence tomography, is described.
References
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Journal ArticleDOI
Computerized transverse axial scanning (tomography): Part I. Description of system. 1973.
TL;DR: A technique in which X-ray transmission readings are taken through the head at a multitude of angles: from these data, absorption values of the material contained within the head are calculated on a computer and presented as a series of pictures of slices of the cranium.
Journal ArticleDOI
Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss.
Alfred Sommer,Joanne Katz,Harry A. Quigley,Neil R. Miller,Alan L. Robin,Ronald C. Richter,Kathe A. Witt +6 more
TL;DR: Nerve fiber layer defects expanded with time, often by the development and coalescence of adjacent areas of damage, and field defects closely corresponded, but nerve fiber layer loss was generally more widespread.
Journal ArticleDOI
Theory and practice of scanning optical microscopy
Tony Wilson,Colin J. R. Sheppard +1 more
Journal ArticleDOI
Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma.
TL;DR: Estimates suggest that visual field sensitivity in automated testing begins to decline soon after the initial loss of ganglion cells in human eyes with glaucoma, and that this decline is most pronounced in areas that had 0-dB sensitivity in the field test.