Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Journal ArticleDOI
Diagnostic capability of optical coherence tomography in evaluating the degree of glaucomatous retinal nerve fiber damage.
TL;DR: RNFL thicknesses in eyes blinded by glaucoma provide an estimate of the component of the RNFL thickness, which is not related to visual function, which may serve as useful adjuncts in accurately and more objectively distinguishing normal fromglaucomatous eyes.
A Comparison of Retinal Morphology Viewed by Optical Coherence Tomography and by Light Microscopy (Laboratory Sciences )
A Cynthia,Stephen A. Msee,Michael R. Msee,G Jim,Cheryl D. Dvm,W. Patrick,From Duke,Narayan,Messrs Boppart,BoIling Afb,Resul Ts +10 more
Journal ArticleDOI
Corneal pachymetry mapping with high-speed optical coherence tomography.
Yan Li,Raj Shekhar,David Huang +2 more
TL;DR: High-speed OCT provided noncontact, rapid, reproducible pachymetric mapping over a wide area of the cornea and is equivalent to ultrasound for CCT measurement before and after LASIK.
Patent
Optical methods for tissue analysis
TL;DR: In this article, the authors proposed a method and system to optically analyze samples such as tissue based on speckle patterns of microscopic motion, such as Brownian motion, which relates to methods and systems for optically analyzing samples.
Journal ArticleDOI
Photothermal detection of gold nanoparticles using phase-sensitive optical coherence tomography.
TL;DR: A new method for detecting gold nanoparticle contrast agents with excellent signal-to-noise performance at high speeds using OCT is demonstrated using a photothermal modulation technique and phase sensitive optical coherence tomography.
References
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