Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Patent
Method and apparatus for performing optical frequency domain reflectometry
Eric A. Swanson,Stephen R. Chinn +1 more
TL;DR: In this paper, an external-cavity frequency-tuned laser with an optical cavity of effective length was used to generate a beat signal in response to the detected beat signal, where the optical coupler couples light from the optical ring to the output port, wherein the wavelength selecting device tunes the center wavelength at a rate equal to the incremental change in frequency caused by the frequency shifter divided by the round trip time of the optical ringing.
Journal ArticleDOI
Analysis of Choroidal Thickness in Age-Related Macular Degeneration Using Spectral-Domain Optical Coherence Tomography
TL;DR: In this paper, the relationship between choroidal thickness and various disease factors in patients with age-related macular degeneration (AMD) using spectral-domain optical coherence tomography was analyzed.
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Characterization of dentin and enamel by use of optical coherence tomography
TL;DR: The group index of refraction for both dentin and enamel was measured at 1.50 +/- 0.02 and 1.62−0.02, respectively as mentioned in this paper.
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Noninvasive Functional Imaging of Human Brain Using Light
David A. Benaron,Susan R. Hintz,Arno Villringer,David A. Boas,Andreas Kleinschmidt,Jens Frahm,Christina Hirth,Hellmuth Obrig,J. C. van Houten,Eben L. Kermit,Wai-Fung Cheong,David K. Stevenson +11 more
TL;DR: In this paper, photon transit time for low-power light passing into the head, and through both skull and brain, of human subjects allowed for tomographic imaging of cerebral hemoglobin oxygenation based on photon diffusion theory.
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Polarization sensitive optical coherence tomography in the human eye.
TL;DR: A variety of different applications of this technique are presented in ocular imaging that are ranging from the anterior to the posterior eye segment and the benefits of the method for imaging different diseases as, e.g., age related macula degeneration or glaucoma is demonstrated.
References
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TL;DR: A technique in which X-ray transmission readings are taken through the head at a multitude of angles: from these data, absorption values of the material contained within the head are calculated on a computer and presented as a series of pictures of slices of the cranium.
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Alfred Sommer,Joanne Katz,Harry A. Quigley,Neil R. Miller,Alan L. Robin,Ronald C. Richter,Kathe A. Witt +6 more
TL;DR: Nerve fiber layer defects expanded with time, often by the development and coalescence of adjacent areas of damage, and field defects closely corresponded, but nerve fiber layer loss was generally more widespread.
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Theory and practice of scanning optical microscopy
Tony Wilson,Colin J. R. Sheppard +1 more
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Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma.
TL;DR: Estimates suggest that visual field sensitivity in automated testing begins to decline soon after the initial loss of ganglion cells in human eyes with glaucoma, and that this decline is most pronounced in areas that had 0-dB sensitivity in the field test.