Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Heidelberg retina Tomography and optical coherence Tomography in normal, ocular-hypertensive, and glaucomatous eyes
Andrea Mistlberger,Jeffrey M. Liebmann,David S. Greenfield,Mauricio E Pons,Sek Tien Hoh,Hiroshi Ishikawa,Robert Ritch +6 more
TL;DR: In this article, the optic disc and retinal nerve fiber layer appearance in normal, ocular-hypertensive, and glaucomatous eyes undergoing confocal scanning laser ophthalmoscopy and optical coherence tomography (OCT) was evaluated.
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Restoration of vision in RPE65-deficient Briard dogs using an AAV serotype 4 vector that specifically targets the retinal pigmented epithelium
G. Le Meur,Knut Stieger,Andrew Smith,Michel Weber,Jack-Yves Deschamps,D. Nivard,Alexandra Mendes-Madeira,Nathalie Provost,Yann Péréon,Yan Cherel,Robin R. Ali,Christian P. Hamel,Philippe Moullier,Fabienne Rolling +13 more
TL;DR: Functional vision was restored in the treated eye, and the dog treated at a later age did not recover retinal function or vision, suggesting that there might be a therapeutic window for the successful treatment of RPE65−/− dogs by gene replacement therapy.
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Optical coherence tomography angiography of the foveal avascular zone in diabetic retinopathy
Florentina J. Freiberg,Maximilian Pfau,Juliana Wons,Magdalena A. Wirth,Matthias D. Becker,Stephan Michels +5 more
TL;DR: The data suggest that OCT angiography can detect disintegrity of the vascular arcades surrounding the FAZ, thus differentiating DM from healthy eyes, and is capable of imaging retinal vasculature without dye injection.
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Array detection for speckle reduction in optical coherence microscopy
TL;DR: A spatial-diversity method for speckle suppression in optical coherence microscopy based on combining interference signals from an array of detectors placed in the back focal plane of the objective lens, such that elements receive light backscattered from the sample volume at different angles is introduced.
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Polarized light interaction with tissues
TL;DR: The substantial reduction of light scattering multiplicity at tissue optical clearing that leads to a lesser influence of scattering on the measured intrinsic polarization properties of the tissue and allows for more precise quantification of these properties is demonstrated.
References
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