Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Journal ArticleDOI
Optical coherence tomography detects characteristic retinal nerve fiber layer thickness corresponding to band atrophy of the optic discs
Akiyasu Kanamori,Makoto Nakamura,Noriko Matsui,Azusa Nagai,Yoriko Nakanishi,Sentaro Kusuhara,Yuko Yamada,Akira Negi +7 more
TL;DR: The degree of RNFL thickness reduction correlated with that of visual field defects, and optical coherence tomography was able to identify the characteristic pattern of R NFL loss in these eyes.
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Imaging the Internal Structure of the Rat Cochlea Using Optical Coherence Tomography at 0.827 μm and 1.3 μm
Brian J. F. Wong,Yonghua Zhao,Mark K. Yamaguchi,Nader Nassif,Zhongping Chen,Johannes F. de Boer +5 more
TL;DR: These images reflect the ability of OCT to provide images of the internal cochlea structure with micron scale resolution and at near-real time frame rates.
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Imaging artificial caries on the occlusal surfaces with polarization-sensitive optical coherence tomography.
TL;DR: There was a strong correlation between the lesion depth calculated from both imaging modalities and the integrated reflectivity of the perpendicular-axis PS-OCT image, quantifying lesion severity, was correlated to the ΔZ of the caries lesions.
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Full-field optical coherence microscopy for identifying live cancer cells by quantitative measurement of refractive index distribution
TL;DR: The feasibility of identifying cancer cells by measuring the refractive index (RI) distribution across a single live cell with ultrahigh resolution full-field optical coherence microscopy (FF-OCM) is presented and showed that cancer cells had higher RI than normal ones.
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Special report: Noninvasive multi-parameter functional optical imaging of the eye.
Darin Nelson,Sara Krupsky,Ayala Pollack,Eyal Aloni,Michael Belkin,Ivo Vanzetta,Mordechai Rosner,Amiram Grinvald +7 more
TL;DR: Direct, noninvasive imaging of four parameters: blood flow, blood oximetry, metabolic state, and hidden vasculature, particularly capillaries are described, which demonstrates a general tool for noninvasively probing retinal function in many modalities.
References
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