Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Removal of a mirror image and enhancement of the signal-to-noise ratio in Fourier-domain optical coherence tomography using an electro-optic phase modulator
TL;DR: A novel swept-laser-based Fourier-domain optical coherence tomography system using an electro-optic phase modulator and elimination of low-frequency noises resulting from dc and autocorrelation terms increased the sensitivity by 20 dB.
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Beyond biomedicine: a review of alternative applications and developments for optical coherence tomography
TL;DR: A detailed overview of the so far presented OCT-based methods and applications, ranging from dimensional metrology, material research and non-destructive testing, over art diagnostics, botany, microfluidics to data storage and security applications, and include new data from a study on penetration depths in various polymer materials.
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Principles of interference microscopy for the measurement of surface topography
TL;DR: Recent advances considered here include performance improvements, vibration robustness, full color imaging, accommodation of highly sloped surfaces, correlation to contact methods, transparent film analysis, and international standardization of calibration and specification.
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Imaging and velocimetry of the human retinal circulation with color Doppler optical coherence tomography.
TL;DR: Color Doppler optical coherence tomography (CDOCT) is demonstrated for the first time in living human subjects for bidirectional blood-flow mapping of retinal vasculature.
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High resolution imaging of in vivo cardiac dynamics using color Doppler optical coherence tomography.
TL;DR: A reconstruction method which overcomes fundamental limitations on Doppler flow mapping associated with both high- and low-speed imaging and is successful in retaining the high velocity resolution of CDOCT while eliminating motion artifact caused by slow image acquisition in samples which exhibit repetitive motion.
References
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