Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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PatentDOI
White Light Diffraction Tomography of Unlabeled Live Cells
Gabriel Popescu,Lynford L. Goddard,Paul Scott Carney,Taewoo Kim,Renjie Zhou,Mustafa Mir,S. Derin Babacan +6 more
TL;DR: In this article, the authors used a temporally incoherent source and light collected in transmission or scattering is used to generate a scattered phase image of the specimen in multiple axial planes, and a derived instrument function is deconvolved to obtain specimen susceptibility in wavevector space.
Journal ArticleDOI
Three-dimensional computation of light scattering from cells
TL;DR: In this article, the scattering cross section and average cosine of the scattering angle are computed for cells as a function of volume fraction of melanin granules and mitochondria, and it is shown that small organelles play a significant role in light scattering from cells.
Journal ArticleDOI
High speed, wide velocity dynamic range Doppler optical coherence tomography (Part I): System design, signal processing, and performance
Victor X. D. Yang,Maggie L. Gordon,Bing Qi,Julius Pekar,Stuart Lo,Emily Seng-Yue,Alvin Mok,Brian C. Wilson,I. Alex Vitkin +8 more
TL;DR: Improvements in real-time Doppler optical coherence tomography (DOCT), acquiring up to 32 frames per second at 250 x 512 pixels per image, are reported using signal processing techniques commonly employed in Dopplers ultrasound imaging.
Journal ArticleDOI
In vivo cellular optical coherence tomography imaging.
Stephen A. Boppart,Brett E. Bouma,Costas Pitris,James F. Southern,Mark E. Brezinski,James G. Fujimoto +5 more
Journal ArticleDOI
Optical coherence tomography based angiography [Invited].
Chieh-Li Chen,Ruikang K. Wang +1 more
TL;DR: A technical oriented overview of the OCTA developments and their potential pre-clinical and clinical applications, and to shed some lights on its future perspectives is provided.
References
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