Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
More filters
Journal ArticleDOI
Optic nerve head and retinal nerve fiber layer analysis: a report by the American Academy of Ophthalmology.
Shan C. Lin,Kuldev Singh,Henry D. Jampel,Elizabeth Hodapp,Scott D. Smith,Brian A. Francis,David K. Dueker,Robert D. Fechtner,John S. Samples,Joel S. Schuman,Don S. Minckler +10 more
TL;DR: The ONH and RNFL imaging instruments reviewed in this assessment were determined to be highly effective in distinguishing eyes with glaucomatous visual field (VF) loss from normal eyes without VF loss, based on level II evidence.
Journal ArticleDOI
Characterization of collagen orientation in human dermis by two-dimensional second-harmonic-generation polarimetry.
TL;DR: Results imply that the reticular dermis posses a tangled structure of collagen fibers, which is highly consistent with the result of the anatomical examination of the skin.
Journal ArticleDOI
New and Current Clinical Imaging Techniques to Study Chronic Obstructive Pulmonary Disease
TL;DR: An overview of novel imaging modalities in the context of COPD are provided and their strengths as well as their limitations for providing quantitative COPD phenotypes are discussed.
Journal ArticleDOI
Measurement of corneal thickness by low-coherence interferometry
TL;DR: In this paper, a superluminescent diode was used as a light source to obtain a precision of 1.5 microm, which is 3-8 times better than the precision of existing instruments.
Journal ArticleDOI
Quantitative thickness measurement of retinal layers imaged by optical coherence tomography.
TL;DR: In this article, a dedicated software algorithm was developed to process the raw OCT images and detect the depth location of peaks from intensity profiles, and quantitative thickness measurements of three retinal layers in addition to total retinal thickness were derived.
References
More filters
Journal ArticleDOI
Computerized transverse axial scanning (tomography): Part I. Description of system. 1973.
TL;DR: A technique in which X-ray transmission readings are taken through the head at a multitude of angles: from these data, absorption values of the material contained within the head are calculated on a computer and presented as a series of pictures of slices of the cranium.
Journal ArticleDOI
Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss.
Alfred Sommer,Joanne Katz,Harry A. Quigley,Neil R. Miller,Alan L. Robin,Ronald C. Richter,Kathe A. Witt +6 more
TL;DR: Nerve fiber layer defects expanded with time, often by the development and coalescence of adjacent areas of damage, and field defects closely corresponded, but nerve fiber layer loss was generally more widespread.
Journal ArticleDOI
Theory and practice of scanning optical microscopy
Tony Wilson,Colin J. R. Sheppard +1 more
Journal ArticleDOI
Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma.
TL;DR: Estimates suggest that visual field sensitivity in automated testing begins to decline soon after the initial loss of ganglion cells in human eyes with glaucoma, and that this decline is most pronounced in areas that had 0-dB sensitivity in the field test.