Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Optical coherence tomography is less sensitive than visual evoked potentials in optic neuritis
Robert T. Naismith,Nhial T. Tutlam,Junqian Xu,J. Shepherd,Eric C. Klawiter,Sheng-Kwei Song,Anne H. Cross +6 more
TL;DR: Optical coherence tomography measures were unrelated to disability and demographic features predicting a worse prognosis in multiple sclerosis, and remains a valuable research tool for studying optic nerve disease in populations.
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Optical coherence tomography of the rat cochlea.
TL;DR: OCT was used to image internal structures in the cochlea without violating the osseous labyrinth using simple surgical exposure of the promontory, and may potentially be used to diagnose inner ear pathology in vivo in both animal and human subjects labyrinth.
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Adaptive optics enhanced simultaneous en-face optical coherence tomography and scanning laser ophthalmoscopy
TL;DR: The correction of aberrations produced by the adaptive optics closed-loop system increased the signal-to-noise ratio in images obtained from volunteer eyes by up to 6 dB in the OCT channel and up to 9dB in the SLO channel.
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Computational high-resolution optical imaging of the living human retina
Nathan D. Shemonski,Fredrick A. South,Yuan Zhi Liu,Steven G. Adie,P. Scott Carney,Stephen A. Boppart +5 more
TL;DR: A fully automated computational approach is demonstrated that enables high-resolution in vivo ophthalmic imaging without the need for hardware-based adaptive optics and demonstrates that computational methods in coherent microscopy are applicable in highly dynamic living systems.
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Adaptive optics optical coherence tomography at 120,000 depth scans/s for non-invasive cellular phenotyping of the living human retina
C. Torti,Boris Povazay,Bernd Hofer,Angelika Unterhuber,Joseph Carroll,Peter K. Ahnelt,Wolfgang Drexler +6 more
TL;DR: A successful combination of ultra-high speed (120,000 depth scans/s), ultra- high resolution optical coherence tomography with adaptive optics and an achromatizing lens for compensation of monochromatic and longitudinal chromatic ocular aberrations, allowing for non-invasive volumetric imaging in normal and pathologic human retinas at cellular resolution is presented.
References
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