Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
More filters
Journal ArticleDOI
Polarization-modulated second harmonic generation in collagen.
TL;DR: The ability to discriminate among different patterns of fibrillar orientation, as exemplified by tendon, fascia, cornea, and successive lamellar rings in an intervertebral disc, is demonstrated.
Journal ArticleDOI
Relationship between Cognitive Impairment and Retinal Morphological and Visual Functional Abnormalities in Alzheimer Disease
TL;DR: This study confirms some other studies in showing that in AD patients there is a reduction of parapapillary and macular RNFL thickness and Macular volume as measured by OCT, and this reduction was related to the severity of cognitive impairment.
Journal ArticleDOI
Mapping of Macular Substructures with Optical Coherence Tomography for Glaucoma Diagnosis
TL;DR: In this article, the authors used OCT images to identify specific retinal layers and macular regions damaged in glaucoma and found that a combination of the 3 innermost layers seems to provide optimal detection of glauchea.
Journal ArticleDOI
Optical polarization imaging
TL;DR: A novel technique is demonstrated for noninvasive surface and beneath-the-surface imaging of biological systems using parallel and perpendicular polarization components of a light pulse backscattered from a scattering medium.
Journal ArticleDOI
Imaging in vivo : watching the brain in action
Jason N. D. Kerr,Winfried Denk +1 more
TL;DR: The limits of what can be achieved in vivo have been pushed into terrain that was previously only accessible in vitro, due to advances in both physical-imaging technology and the design of molecular contrast agents.
References
More filters
Journal ArticleDOI
Computerized transverse axial scanning (tomography): Part I. Description of system. 1973.
TL;DR: A technique in which X-ray transmission readings are taken through the head at a multitude of angles: from these data, absorption values of the material contained within the head are calculated on a computer and presented as a series of pictures of slices of the cranium.
Journal ArticleDOI
Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss.
Alfred Sommer,Joanne Katz,Harry A. Quigley,Neil R. Miller,Alan L. Robin,Ronald C. Richter,Kathe A. Witt +6 more
TL;DR: Nerve fiber layer defects expanded with time, often by the development and coalescence of adjacent areas of damage, and field defects closely corresponded, but nerve fiber layer loss was generally more widespread.
Journal ArticleDOI
Theory and practice of scanning optical microscopy
Tony Wilson,Colin J. R. Sheppard +1 more
Journal ArticleDOI
Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma.
TL;DR: Estimates suggest that visual field sensitivity in automated testing begins to decline soon after the initial loss of ganglion cells in human eyes with glaucoma, and that this decline is most pronounced in areas that had 0-dB sensitivity in the field test.