Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
More filters
Journal ArticleDOI
Neointimal coverage of bare-metal and sirolimus-eluting stents evaluated with optical coherence tomography
TL;DR: OCT imaging can clearly visualise stent apposition and neointimal coverage of stent struts, and these findings may explain the occurrence of late thrombosis in SES.
Journal ArticleDOI
Correction of distortions in optical coherence tomography imaging of the eye.
TL;DR: This work investigates errors in imaging different tissue: cornea and retina in vivo and an intraocular lens in vitro, and shows that the axial distortion can be larger than the achievable depth resolution in modern OCT systems.
Journal ArticleDOI
Advanced image processing for optical coherence tomographic angiography of macular diseases
Miao Zhang,Jie Wang,Alex D. Pechauer,Thomas S. Hwang,Simon S. Gao,Liang Liu,Li Liu,Steven T. Bailey,David J. Wilson,David Huang,Yali Jia +10 more
TL;DR: An overview of advanced image processing for three dimensional (3D) optical coherence tomographic (OCT) angiography of macular diseases, including age-related macular degeneration and diabetic retinopathy is provided.
Journal ArticleDOI
Investigation of optical coherence tomography as an imaging modality in tissue engineering.
TL;DR: This study investigates optical coherence tomography as an imaging modality to monitor non-invasively both structures and cells in engineered tissue constructs, and employs time-domain OCT to visualize macro-structural morphology, and whole-field Optical coherence microscopy to delineate the morphology of cells and constructs in a developing in vitro engineered bone tissue.
Journal ArticleDOI
Polarization effects in optical coherence tomography of various biological tissues
J. F. de Boer,Shyam M. Srinivas,B.H. Park,T.H. Pham,Zhongping Chen,Thomas E. Milner,J.S. Nelson +6 more
TL;DR: Polarization sensitive optical coherence tomography (PS-OCT) was used to obtain spatially resolved ex vivo images of polarization changes in skeletal muscle, bone, skin and brain and the effects of single polarization state detection on OCT image formation is demonstrated.
References
More filters
Journal ArticleDOI
Computerized transverse axial scanning (tomography): Part I. Description of system. 1973.
TL;DR: A technique in which X-ray transmission readings are taken through the head at a multitude of angles: from these data, absorption values of the material contained within the head are calculated on a computer and presented as a series of pictures of slices of the cranium.
Journal ArticleDOI
Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss.
Alfred Sommer,Joanne Katz,Harry A. Quigley,Neil R. Miller,Alan L. Robin,Ronald C. Richter,Kathe A. Witt +6 more
TL;DR: Nerve fiber layer defects expanded with time, often by the development and coalescence of adjacent areas of damage, and field defects closely corresponded, but nerve fiber layer loss was generally more widespread.
Journal ArticleDOI
Theory and practice of scanning optical microscopy
Tony Wilson,Colin J. R. Sheppard +1 more
Journal ArticleDOI
Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma.
TL;DR: Estimates suggest that visual field sensitivity in automated testing begins to decline soon after the initial loss of ganglion cells in human eyes with glaucoma, and that this decline is most pronounced in areas that had 0-dB sensitivity in the field test.