Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Journal ArticleDOI
Choroidal imaging using spectral-domain optical coherence tomography
TL;DR: In this article, a structurally and functionally normal choroidal vasculature is essential for retinal function and a precise clinical understanding of choroid morphology should be important for understanding many retinal and chorionic diseases.
Patent
Enhancing contrast in biological imaging
TL;DR: In this paper, a contrast agent such as acetic acid, toluidine blue, hypertonic saline, hypotonic saline, Lugol's iodine, an absorbing dye, a liposome, or contrast agent linked to a marker are applied to a sample.
Journal ArticleDOI
Phase-Domain Processing of Optical Coherence Tomography Images
TL;DR: An OCT system that incorporates a quadrature-demodulation scheme for accurate recording of the phase and amplitude of OCT signals from single or multiple detectors and a speckle-reduction technique that works in the complex domain, called the zero-adjustment procedure (ZAP), is investigated as an example of complex-domain processing.
Journal ArticleDOI
Gold nanocages for cancer detection and treatment
TL;DR: The results show improved optical coherence tomography image contrast when Au nanocages are added to tissue phantoms as well as the selective photothermal destruction of breast cancer cells in vitro when immunotargeted Au nanOCages are used.
Journal ArticleDOI
Optical coherence tomography.
TL;DR: The principles and performances of different OCT techniques are discussed, and images from different types of tissue are presented, and highly adventurous avenues to expand the OCT capabilities and trends are presented.
References
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