Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Remodeling of the human retina in choroideremia: rab escort protein 1 (REP-1) mutations.
Samuel G. Jacobson,Artur V. Cideciyan,Alexander Sumaroka,Tomas S. Aleman,Sharon B. Schwartz,Elizabeth A. M. Windsor,Alejandro J. Roman,Edwin M. Stone,Ian M. MacDonald +8 more
TL;DR: The results represent in vivo evidence in humans for retinal remodeling and provide a marker for the earliest stage of this response to genetic retinal disease, which may be due to Müller cell activation and hypertrophy from photoreceptor stress.
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Efficient reduction of speckle noise in Optical Coherence Tomography
Maciej Szkulmowski,Iwona Gorczynska,Daniel Szlag,Marcin Sylwestrzak,Andrzej Kowalczyk,Maciej Wojtkowski +5 more
TL;DR: This work proposes to average multiple A-scans collected in a fully controlled way to reduce the speckle contrast, which is immune to bulk motion of an investigated sample, and does not require any sophisticated data processing to align cross-sectional images.
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Optical Coherence Tomography for Neurosurgical Imaging of Human Intracortical Melanoma
TL;DR: OCT can effectively differentiate normal cortex from intracortical melanoma based on variations in optical backscatter, and may permit the intraoperative identification of tumor and the more precise localization of tumor margins.
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Anterior chamber angle assessment techniques.
David S. Friedman,Mingguang He +1 more
TL;DR: Gonioscopy, ultrasound biomicroscopy, and anterior segment optical coherence tomography are reviewed, all of which can be used to assess the anterior chamber angle directly and surrogate approaches to measuring the angle configuration are discussed.
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Differential phase contrast in optical coherence tomography.
TL;DR: A modification of optical coherence tomography (OCT) that allows one to measure small phase differences between beams traversing adjacent areas of a specimen and determine path-difference gradients with a resolution of the order of 5 x 10(-5) .
References
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Journal ArticleDOI
Computerized transverse axial scanning (tomography): Part I. Description of system. 1973.
TL;DR: A technique in which X-ray transmission readings are taken through the head at a multitude of angles: from these data, absorption values of the material contained within the head are calculated on a computer and presented as a series of pictures of slices of the cranium.
Journal ArticleDOI
Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss.
Alfred Sommer,Joanne Katz,Harry A. Quigley,Neil R. Miller,Alan L. Robin,Ronald C. Richter,Kathe A. Witt +6 more
TL;DR: Nerve fiber layer defects expanded with time, often by the development and coalescence of adjacent areas of damage, and field defects closely corresponded, but nerve fiber layer loss was generally more widespread.
Journal ArticleDOI
Theory and practice of scanning optical microscopy
Tony Wilson,Colin J. R. Sheppard +1 more
Journal ArticleDOI
Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma.
TL;DR: Estimates suggest that visual field sensitivity in automated testing begins to decline soon after the initial loss of ganglion cells in human eyes with glaucoma, and that this decline is most pronounced in areas that had 0-dB sensitivity in the field test.