Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Patent
Arrangements and methods for providing multimodality microscopic imaging of one or more biological structures
TL;DR: In this paper, a method and apparatus according to an exemplary embodiment of the present invention can be provided, where first data associated with a first signal received from at least one region of at least 1 sample can be obtained based on a first modality.
Journal ArticleDOI
Noise analysis of a combined optical coherence tomograph and a confocal scanning ophthalmoscope.
TL;DR: In this paper, a fiberized optical coherence tomographic (OCT) system is modified to produce a confocal image similar to that produced by a scanning laser ophthalmoscope.
Journal ArticleDOI
Video-rate optical low-coherence reflectometry based on a linear smart detector array.
TL;DR: A low-coherence reflectometer based on a conventional Michelson interferometer and a novel silicon detector chip that allows parallel heterodyne detection is presented and applications in surface profiling and thickness measurement are demonstrated.
Journal ArticleDOI
Large Field, High Resolution Full-Field Optical Coherence Tomography: A Pre-Clinical Study of Human Breast Tissue and Cancer Assessment:
Osnath Assayag,Martine Antoine,Brigitte Sigal-Zafrani,Michael Riben,Fabrice Harms,Adriano Burcheri,Kate Grieve,Eugénie Dalimier,Bertrand Le Conte Chrestien De Poly,Claude Boccara +9 more
TL;DR: In this article, the authors presented a benchmark pilot study in which high-resolution Full-Field Optical Coherence Tomography (FF-OCT) was used to image human breast tissue and is evaluated to assess its ability to aid the pathologist's management of intra-operative diagnoses.
Journal ArticleDOI
High-speed ultra-high-resolution optical coherence tomography findings in hydroxychloroquine retinopathy
Julio A. Rodriguez-Padilla,Thomas R. Hedges,B.K. Monson,Vivek J. Srinivasan,Maciej Wojtkowski,Maciej Wojtkowski,Elias Reichel,Jay S. Duker,Joel S. Schuman,James G. Fujimoto +9 more
TL;DR: Distinctive abnormalities in the perifoveal photoreceptor inner segment/outer segment junction were seen on hsUHR-OCT in patients receiving hydroxychloroquine who also were symptomatic and had abnormalities on automated visual fields and mfERG.
References
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