Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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The relationship between retinal ganglion cell function and retinal nerve fiber thickness in early glaucoma.
TL;DR: In early glaucoma, reduction in RGC electrical activity exceeds the proportion expected from lost RGC axons, suggesting that a population of viable RGCs in the central retina is dysfunctional.
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Macular thickness decreases with age in normal eyes. A study on the macular thickness map protocol in the Stratus OCT
Urban Eriksson,Albert Alm +1 more
TL;DR: Retinal thickness within the area covered by the macular map significantly decreases with age, and in the area examined in the papillomacular bundle, 20% of the retinal thinning is due to the RNFL, and 80% isdue to thinning of other layers of the retina.
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Diagnosing glaucoma progression with optical coherence tomography.
TL;DR: The analyses of the RNFL thickness map, lamina cribrosa displacement and inner macular thickness have provided a new paradigm to evaluate glaucomatous damage and its progression.
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Line-field confocal optical coherence tomography for high-resolution noninvasive imaging of skin tumors.
Arnaud Dubois,Olivier Levecq,Hicham Azimani,David Siret,Anaiss Barut,Mariano Suppa,Véronique Del Marmol,Josep Malvehy,Elisa Cinotti,Pietro Rubegni,Jean-Luc Perrot +10 more
TL;DR: The use of LC-OCT as an adjunct tool in medical practice could significantly improve clinical diagnostic accuracy while reducing the number of biopsies of benign lesions.
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En face imaging of single cell layers by differential phase-contrast optical coherence microscopy.
Markus Sticker,Michael Pircher,Erich Götzinger,Harald Sattmann,Adolf Friedrich Fercher,Christoph K. Hitzenberger +5 more
TL;DR: A combination of OCM with a differential phase-contrast technique that permits imaging of the subwavelength optical path differences that occur between a narrow beam probing a sample and its surrounding is reported on.
References
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