Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Journal ArticleDOI
Time-resolved fluorescence and photon migration studies in biomedical and model random media
TL;DR: In this article, a review highlights time-resolved fluorescence kinetics and photon transport in tissues and other biomedical media with a special emphasis on ultrafast measurements of key optical parameters.
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Imaging of the optic disc and retinal nerve fiber layer: the effects of age, optic disc area, refractive error, and gender.
Christopher Bowd,Linda M. Zangwill,Eytan Z. Blumenthal,Cristiana Vasile,Andreas G. Boehm,Parag A. Gokhale,Kourosh Mohammadi,Payam Amini,Timothy M. Sankary,Robert N. Weinreb +9 more
TL;DR: Although effects of age on the optic disc and RNFL are small, they should be considered in monitoring ocular disease and when cross-sectionally evaluating disc topography and, to a lesser extent, RNFL thickness.
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Choroidal Structure in Normal Eyes and After Photodynamic Therapy Determined by Binarization of Optical Coherence Tomographic Images
Shozo Sonoda,Taiji Sakamoto,Takehiro Yamashita,Makoto Shirasawa,Eisuke Uchino,Hiroto Terasaki,Masatoshi Tomita +6 more
TL;DR: The Niblack binarization method can be used to analyze the luminal area of choroid in an OCT image with good repeatability and reproducibility and the change in the subfoveal choroidal area after PDT is due mainly to a decrease in the Luminal areas.
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Speckle reduction in optical coherence tomography images using digital filtering.
TL;DR: In this article, the authors apply various speckle-reduction digital filters to optical coherence tomography images and compare their performance, showing that shift-invariant, nonorthogonal wavelet-transform-based filters together with enhanced Lee and adaptive Wiener filters can significantly reduce speckble and increase the signal-to-noise ratio, while preserving strong edges.
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High-speed volumetric imaging of cone photoreceptors with adaptive optics spectral-domain optical coherence tomography
Yan Zhang,Barry Cense,Jungtae Rha,Ravi S. Jonnal,W. Gao,Robert J. Zawadzki,John S. Werner,Steve Jones,Scot S. Olivier,Donald T. Miller +9 more
TL;DR: The first observations of the three-dimensional morphology of cone photoreceptors in the living human retina are reported, with regular distribution of bright spots observed within C-scans at the inner segment / outer segment (IS/OS) junctions and at the posterior tips of the OS were found to be highly correlated with one another and with the expected cone spacing.
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