Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Journal ArticleDOI
Multiple scattering in optical coherence microscopy
TL;DR: It is shown that the multiple-scatter rejection provided by optical coherence microscopy (low-coherence interferometry) can be incomplete in optically turbid media and that multiple scattering manifests itself in two distinct ways.
Journal ArticleDOI
Clinical application of rapid serial fourier-domain optical coherence tomography for macular imaging.
S. Alam,Robert J. Zawadzki,Stacey S. Choi,Christina Gerth,Susanna Soon Chun Park,Lawrence S Morse,John S. Werner +6 more
TL;DR: This technique provides additional information that can be missed on single OCT images and provides an accurate way to image large or complex lesions, and allows B-scan and C-scan reconstructions to be made that provide additional perspectives into retinal structures that may be missed using traditional imaging methods.
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Wavelet denoising of multiframe optical coherence tomography data.
Markus A. Mayer,Anja Borsdorf,Martin G. Wagner,Joachim Hornegger,Christian Y. Mardin,Ralf P. Tornow +5 more
TL;DR: A novel speckle noise reduction algorithm for OCT images that uses wavelet decompositions of the single frames for a local noise and structure estimation and observes only a minor sharpness decrease at a signal-to-noise gain.
Journal ArticleDOI
Automated detection of exudative age-related macular degeneration in spectral domain optical coherence tomography using deep learning.
TL;DR: With a deep learning-based approach using TensorFlow™, it is possible to detect AMD in SD-OCT with high sensitivity and specificity.
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Multimodal photoacoustic and optical coherence tomography scanner using an all optical detection scheme for 3D morphological skin imaging.
Edward Z. Zhang,Boris Povazay,Jan Laufer,Aneesh Alex,Bernd Hofer,Barbara Pedley,Carl Glittenberg,Bradley E. Treeby,Ben T. Cox,Paul C. Beard,Wolfgang Drexler +10 more
TL;DR: Three-dimensional in vivo images of the vasculature and the surrounding tissue micro-morphology in murine and human skin were acquired and complementary contrast and tissue information provided by each modality for high-resolution 3D imaging of vascular structures to depths of up to 5 mm.
References
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