Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Macular traction detachment and diabetic macular edema associated with posterior hyaloidal traction
TL;DR: Eyes with DME associated with PHT may have a shallow, subclinical, macular detachment, and optical coherence tomography may be useful in evaluating patients with D ME to see if a macular detached is present.
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High-resolution imaging of gynecologic neoplasms using optical coherence tomography
Costas Pitris,Annekathryn Goodman,Stephen A. Boppart,Jennifer J. Libus,James G. Fujimoto,Mark E. Brezinski +5 more
TL;DR: Optical coherence tomography of tissue microstructures showed potential for powerful, minimally invasive assessment of the female reproductive tract at a resolution greater than any current clinical imaging method.
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Optical tomography-measured retinal nerve fiber layer thickness in normal latinos.
TL;DR: The average peripapillary and macular RNFL thickness was significantly thinner in older Latinos than in younger Latinos (P = 0.04 and P = 0.0001, respectively) as discussed by the authors.
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Twenty-five years of optical coherence tomography: the paradigm shift in sensitivity and speed provided by Fourier domain OCT [Invited]
TL;DR: This review paper points out the key aspects of the physics and the technology that has enabled a more than 2 orders of magnitude increase in sensitivity, and as a consequence an increase in the imaging speed without loss of image quality.
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Segmentation of Intra-Retinal Layers From Optical Coherence Tomography Images Using an Active Contour Approach
TL;DR: A semi-automated segmentation algorithm to detect intra-retinal layers in OCT images acquired from rodent models of retinal degeneration is presented, demonstrating the strength of the method to detect the desired retinal layers with sufficient accuracy even in the presence of intensity inhomogeneity resulting from blood vessels.
References
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