Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Journal ArticleDOI
Review of polarization sensitive optical coherence tomography and Stokes vector determination.
TL;DR: The theory and calculation of the Stokes vector of light reflected from turbid media is described, application of PS-OCT to contemporary biomedical imaging problems is given and effect of multiple scattering and speckle on the accuracy and noise of the computed Stokes parameters is discussed.
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Full range complex spectral optical coherence tomography technique in eye imaging
TL;DR: By reconstruction of both amplitude and phase, a new implementation of complex spectral optical coherence tomography (OCT) in biomedical imaging is demonstrated, able to use the negative and positive optical path differences to get images of objects of considerable thickness.
Journal ArticleDOI
Quantifying axonal loss after optic neuritis with optical coherence tomography.
Fiona Costello,Stuart G Coupland,William Hodge,Gianni R. Lorello,Jeannie Koroluk,Y. Irene Pan,Mark S. Freedman,David H. Zackon,Randy H. Kardon +8 more
TL;DR: To determine to what degree changes in retinal nerve fiber layer (RNFL) thickness after optic neuritis (ON) correlate with either visual recovery or impairment, a large number of animals have been fitted with RNFLs and the results have shown associations with visual recovery and impairment.
Quantitative Optical Coherence Tomography Angiography of Choroidal Neovascularization in Age-Related Macular Degeneration
Yali Jia,Steven T. Bailey,David J. Wilson,Ou Tan,Michael L. Klein,Christina J. Flaxel,Benjamin Potsaid,Benjamin Potsaid,Jonathan J. Liu,Chen D. Lu,Martin F. Kraus,Martin F. Kraus,James G. Fujimoto,David Huang +13 more
TL;DR: In this article, the authors used OCT angiograms to detect and quantify choroidal neovascularization (CNV) in patients with age-related macular degeneration (AMD) using optical coherence tomography (OCT) angiography.
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Optical Coherence Tomography Measurement of Macular and Nerve Fiber Layer Thickness in Normal and Glaucomatous Human Eyes
Viviane Guedes,Viviane Guedes,Joel S. Schuman,Ellen Hertzmark,Ellen Hertzmark,Gadi Wollstein,Anthony J Correnti,Ronald Mancini,David E. Lederer,Serineh Voskanian,Leonardo Velazquez,Helena M. Pakter,Helena M. Pakter,Tamar Pedut-Kloizman,James G. Fujimoto,Cynthia Mattox +15 more
TL;DR: Both macular and NFL thickness as measured by OCT showed statistically significant correlations with glaucoma, although NFL thickness showed a stronger association than macular thickness.
References
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