Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
More filters
Journal ArticleDOI
Reproducibility of Retinal Thickness Measurements on Normal and Pathologic Eyes by Different Optical Coherence Tomography Instruments
Andrea Giani,Andrea Giani,Mario Cigada,Netan Choudhry,Antonio Peroglio Deiro,Marta Oldani,Marco Antonio Pellegrini,Alessandro Invernizzi,Piergiorgio Duca,Joan W. Miller,Giovanni Staurenghi +10 more
TL;DR: In this article, the authors compare retinal thickness measurements produced by different time-domain and spectral-domain optical coherence tomography (TD-OCT) devices when imaging normal and pathologic eyes.
Journal ArticleDOI
Fluorescence lifetime imaging of unstained tissues: early results in human breast cancer
Paul J. Tadrous,Jan Siegel,Paul Mw French Paul Mw French Paul Mw French,Sami Shousha,El-Nasir Lalani,Gordon Wh Stamp Gordon Wh Stamp Gordon Wh Stamp +5 more
TL;DR: Fluorescence lifetime imaging (FLIM) has been applied to fixed (but unstained) breast cancer tissues to demonstrate the feasibility of this approach for histopathological assessment in this article.
Journal ArticleDOI
Variation of peripapillary retinal nerve fiber layer birefringence in normal human subjects.
TL;DR: RNFL birefringence varies with position around the ONH, and variation may result from known structural differences among nerve fiber bundles that serve different retinal regions, which may provide a means to detect early subcellular changes in glaucoma.
Patent
Method and apparatus for imaging of vessel segments
TL;DR: In this paper, an apparatus, method and software arrangement for imaging a surface of a structure that is in contact with an opaque fluid is provided, which includes an article of manufacture (e.g., a housing), a fluid delivery arrangement and an imaging arrangement.
Journal ArticleDOI
Optical coherence tomography 3: Automatic delineation of the outer neural retinal boundary and its influence on retinal thickness measurements.
R. A. Costa,Daniela Calucci,M. Skaf,Jose A. Cardillo,J.C. Castro,Luiz Alberto S. Melo,Maria Cristina Martins,Peter K. Kaiser +7 more
TL;DR: Investigation of the automatic delineation of the outer limits of the macular neural retina by using the optical coherence tomography (OCT)-3 built-in software foundorrect delineators are occurring with the automated retinal thickness measurement tool of the OCT3 software.
References
More filters
Journal ArticleDOI
Computerized transverse axial scanning (tomography): Part I. Description of system. 1973.
TL;DR: A technique in which X-ray transmission readings are taken through the head at a multitude of angles: from these data, absorption values of the material contained within the head are calculated on a computer and presented as a series of pictures of slices of the cranium.
Journal ArticleDOI
Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss.
Alfred Sommer,Joanne Katz,Harry A. Quigley,Neil R. Miller,Alan L. Robin,Ronald C. Richter,Kathe A. Witt +6 more
TL;DR: Nerve fiber layer defects expanded with time, often by the development and coalescence of adjacent areas of damage, and field defects closely corresponded, but nerve fiber layer loss was generally more widespread.
Journal ArticleDOI
Theory and practice of scanning optical microscopy
Tony Wilson,Colin J. R. Sheppard +1 more
Journal ArticleDOI
Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma.
TL;DR: Estimates suggest that visual field sensitivity in automated testing begins to decline soon after the initial loss of ganglion cells in human eyes with glaucoma, and that this decline is most pronounced in areas that had 0-dB sensitivity in the field test.