Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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High resolution imaging of the upper respiratory tract with optical coherence tomography a feasibility study
Costas Pitris,Mark E. Brezinski,Brett E. Bouma,Gary J. Tearney,James F. Southern,James G. Fujimoto +5 more
TL;DR: The ability of OCT to generate image resolution in the range close to that of histopathology in real time, as well as easy integration with small, relatively inexpensive endoscopes, low cost, and lack of a need for a transducing medium, supports the hypothesis that this optical technology could become a powerful modality in the diagnosis and management of a wide range of clinical respiratory pathology.
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Two-dimensional and 3-dimensional optical coherence tomographic imaging of the airway, lung, and pleura.
N. Hanna,D J Saltzman,David Mukai,Zhongping Chen,S. Sasse,Jeffrey C. Milliken,Shuguang Guo,Woonggyu Jung,Henri G. Colt,Matthew Brenner +9 more
TL;DR: Investigation of the feasibility of real-time 2- and 3-dimensional optical coherence tomographic imaging of airway, pleural, and subpleural lung tissues in normal, inflammatory, and malignant animal models and patients with known or suspected airway malignancy finds details at the level of mucosal layers, glands, alveoli, and respiratory bronchioles.
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Imaging the Ocular Anterior Segment With Real-Time, Full-Range Fourier-Domain Optical Coherence Tomography
TL;DR: A novel Fourier-domain optical coherence tomography system and signal-processing algorithm for full-range, real-time, artifact-free quantitative imaging of the anterior chamber is demonstrated.
Journal ArticleDOI
Review of intraoperative optical coherence tomography: technology and applications [Invited]
Oscar Carrasco-Zevallos,Christian Viehland,Brenton Keller,Mark Draelos,Anthony N. Kuo,Cynthia A. Toth,Joseph A. Izatt +6 more
TL;DR: This article reviews key technological developments in intraoperative OCT and their applications in human surgery and focuses on handheld OCT probes, microscope-integrated OCT systems, and OCT-guided laser treatment platforms designed for intraoperative use.
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Effective indicators for diagnosis of oral cancer using optical coherence tomography
Meng-Tsan Tsai,Hsiang-Chieh Lee,Cheng-Kuang Lee,Chuan-Hang Yu,Hsin-Ming Chen,Chun-Pin Chiang,Cheng-Chang Chang,Yih-Ming Wang,Chih-Chung Yang +8 more
TL;DR: A swept-source optical coherence tomography system is used to clinically scan oral precancer and cancer patients for statistically analyzing the effective indicators of diagnosis and it is found that SD and alpha are good diagnosis indicators for moderate dysplasia and squamous cell carcinoma.
References
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