Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Journal ArticleDOI
Comparison of optical coherence tomography and ultrasound biomicroscopy for detection of narrow anterior chamber angles.
Sunita Radhakrishnan,Jason A. Goldsmith,David Huang,Volker Westphal,David K. Dueker,Andrew M. Rollins,Joseph A. Izatt,Joseph A. Izatt,Scott D. Smith,Scott D. Smith +9 more
TL;DR: Optical coherence tomography was similar to UBM in quantitative AC angle measurement and detection of narrow angles and is a promising method for screening individuals at risk for narrow angle glaucoma.
Patent
Method and apparatus for performing optical imaging using frequency-domain interferometry
TL;DR: In this article, the first and/or second electro-magnetic radiations have a spectrum whose mean frequency changes substantially continuously over time at a tuning speed that is greater than 100 Tera Hertz per millisecond.
Patent
System and method for optical coherence imaging
TL;DR: In this paper, a system and method for imaging of a sample, e.g., biological sample, are provided, where at least one source electro-magnetic radiation forwarded to the sample and a reference may be generated.
Journal ArticleDOI
Deep learning is effective for the classification of OCT images of normal versus Age-related Macular Degeneration.
TL;DR: Deep learning techniques achieve high accuracy and is effective as a new image classification technique in Optical coherence tomography and have important implications in utilizing OCT in automated screening and the development of computer aided diagnosis tools in the future.
Journal ArticleDOI
Superresolution Multidimensional Imaging with Structured Illumination Microscopy
Aurélie Jost,Rainer Heintzmann +1 more
TL;DR: In this paper, the authors proposed a method known as optical sectioning SIM (OSSIM) to remove the out-of-focus blur caused by the Moire effect in a wide-field fluorescence microscope.
References
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Journal ArticleDOI
Computerized transverse axial scanning (tomography): Part I. Description of system. 1973.
TL;DR: A technique in which X-ray transmission readings are taken through the head at a multitude of angles: from these data, absorption values of the material contained within the head are calculated on a computer and presented as a series of pictures of slices of the cranium.
Journal ArticleDOI
Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss.
Alfred Sommer,Joanne Katz,Harry A. Quigley,Neil R. Miller,Alan L. Robin,Ronald C. Richter,Kathe A. Witt +6 more
TL;DR: Nerve fiber layer defects expanded with time, often by the development and coalescence of adjacent areas of damage, and field defects closely corresponded, but nerve fiber layer loss was generally more widespread.
Journal ArticleDOI
Theory and practice of scanning optical microscopy
Tony Wilson,Colin J. R. Sheppard +1 more
Journal ArticleDOI
Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma.
TL;DR: Estimates suggest that visual field sensitivity in automated testing begins to decline soon after the initial loss of ganglion cells in human eyes with glaucoma, and that this decline is most pronounced in areas that had 0-dB sensitivity in the field test.