Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence Tomography
Vivek J. Srinivasan,Maciej Wojtkowski,Maciej Wojtkowski,Andre J. Witkin,Jay S. Duker,Tony H. Ko,Mariana T. Carvalho,Joel S. Schuman,Andrzej Kowalczyk,James G. Fujimoto +9 more
TL;DR: High-speed ultrahigh-resolution OCT generates images of retinal pathologies with improved quality, more comprehensive retinal coverage, and more precise registration than standard OCT, and has the potential to become a useful tool for elucidating disease pathogenesis and improving disease diagnosis and management.
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Turbulent nature of refractive-index variations in biological tissue.
Joseph M. Schmitt,Gitesh Kumar +1 more
TL;DR: Phase-contrast microscopy shows that the structure of the refractive-index inhomogeneities in a variety of mammalian tissues resembles that of frozen turbulence, and the observed structure function fits the classical Kolmogorov model of turbulence.
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Three dimensional OCT images from retina and skin.
TL;DR: The en-face optical coherence tomography system, equipped with the 3D rendering feature acts as a valuable diagnostic tool allowing "peeling off" of transversal and longitudinal biologic material to investigate different internal features.
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Photonic device fabrication in glass by use of nonlinear materials processing with a femtosecond laser oscillator
TL;DR: Optical coherence tomography shows large refractive-index changes of up to ~10(-2) in the waveguides; these changes are consistent with guided mode analysis.
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Retinal thickness measurements from optical coherence tomography using a Markov boundary model
TL;DR: Qualitatively, the boundaries detected by the automated system generally agreed extremely well with the true retinal structure for the vast majority of OCT images, and a robust, quantitatively accurate system can be expected to improve patient care.
References
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