Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Journal ArticleDOI
Characterization of fluid flow velocity by optical Doppler tomography
TL;DR: Optical Doppler tomography is an accurate method for the characterization of high-resolution fluid flow velocity in transparent glass and turbid collagen conduits and is in excellent agreement with experimental data and theoretical calculations.
Journal ArticleDOI
Optical Coherence Tomography: History, Current Status, and Laboratory Work
Michelle L. Gabriele,Michelle L. Gabriele,Gadi Wollstein,Hiroshi Ishikawa,Larry Kagemann,Juan Xu,Lindsey S. Folio,Joel S. Schuman +7 more
TL;DR: The history of OCT imaging of the eye, its current status, and the laboratory work that is driving the future of the technology are reviewed.
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In vivo total retinal blood flow measurement by Fourier domain Doppler optical coherence tomography
TL;DR: In vivo normal human volumetric retinal flow measurement using Fourier domain Doppler optical coherence tomography is presented, believed to be the first demonstration of total retinal blood flow Measurement using the OCT technique.
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Spectral shaping for non-Gaussian source spectra in optical coherence tomography.
TL;DR: A digital spectral shaping technique to reduce the sidelobes (ringing) of the axial point-spread function in optical coherence tomography for non-Gaussian-shaped source spectra is presented.
Journal ArticleDOI
Oxygen saturation-dependent absorption and scattering of blood.
Dirk J. Faber,Maurice C. G. Aalders,Egbert G. Mik,Brett A. Hooper,Martin J. C. van Gemert,Ton G. van Leeuwen,Ton G. van Leeuwen +6 more
TL;DR: The complex refractive index of oxygenated and deoxygenated hemoglobin is determined using a Kramers-Kronig analysis and optical coherence tomography measurements and the scattering properties are calculated using Mie theory.
References
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Journal ArticleDOI
Computerized transverse axial scanning (tomography): Part I. Description of system. 1973.
TL;DR: A technique in which X-ray transmission readings are taken through the head at a multitude of angles: from these data, absorption values of the material contained within the head are calculated on a computer and presented as a series of pictures of slices of the cranium.
Journal ArticleDOI
Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss.
Alfred Sommer,Joanne Katz,Harry A. Quigley,Neil R. Miller,Alan L. Robin,Ronald C. Richter,Kathe A. Witt +6 more
TL;DR: Nerve fiber layer defects expanded with time, often by the development and coalescence of adjacent areas of damage, and field defects closely corresponded, but nerve fiber layer loss was generally more widespread.
Journal ArticleDOI
Theory and practice of scanning optical microscopy
Tony Wilson,Colin J. R. Sheppard +1 more
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Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma.
TL;DR: Estimates suggest that visual field sensitivity in automated testing begins to decline soon after the initial loss of ganglion cells in human eyes with glaucoma, and that this decline is most pronounced in areas that had 0-dB sensitivity in the field test.