Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Journal ArticleDOI
Ocular surface epithelial thickness evaluation with spectral-domain optical coherence tomography.
TL;DR: Anterior segment SD-OCT can provide a noninvasive evaluation of ocular surface epithelial thickness and was modified in dry eye patients and patients using IOP-lowering eye drops, whereas aging seemed to have no effect.
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3D morphometry of red blood cells by digital holography.
Pasquale Memmolo,Lisa Miccio,Francesco Merola,Oriella Gennari,Paolo A. Netti,Paolo A. Netti,Pietro Ferraro +6 more
TL;DR: This work proves the new procedure for healthy red blood cells (RBCs) (i.e., discocytes) having a concave surface in their central region and shows that the method can be also useful to classify, in terms of morphology, different varieties of RBCs.
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High-sensitivity determination of birefringence in turbid media with enhanced polarization-sensitive optical coherence tomography
TL;DR: In this article, a method for high-sensitivity birefringence quantification by using enhanced polarization-sensitive optical coherence tomography (EPS-OCT) is presented.
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Three-dimensional endomicroscopy of the human colon using optical coherence tomography.
Desmond C. Adler,Chao Zhou,Tsung-Han Tsai,Joe Schmitt,Qin Huang,Hiroshi Mashimo,James G. Fujimoto +6 more
TL;DR: The potential of 3D-OCT for distinguishing normal from pathologic colorectal tissue, assessing endoscopic therapies and healing progression is demonstrated in vivo using a swept source optical coherence tomography (OCT) system.
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Diagnostic capability of optical coherence tomography (Stratus OCT 3) in early glaucoma
Rajul S Parikh,Shefali Parikh,G. Chandra Sekhar,Rajesh S. Kumar,S. Prabakaran,J. Ganesh Babu,Ravi Thomas +6 more
TL;DR: Optical coherence tomography has moderate sensitivity with high specificity for the diagnosis of early glaucoma and may have a potential role in screening.
References
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