Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography
TL;DR: In this paper, a single scattering model and a recently developed description of the confocal point spread function (PSF) were used to extract the attenuation coefficient with an accuracy of 0.8 mm-1.
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Transversal and longitudinal images from the retina of the living eye using low coherence reflectometry
Adrian Gh. Podoleanu,Mauritius Seeger,George Dobre,David J. Webb,David A. Jackson,Fred W. Fitzke +5 more
TL;DR: An optical coherence tomography (OCT) system to produce both longitudinal and transversal images of the in vivo human eye is presented in this article, where a path modulation is introduced by the galvanometric scanning mirror and is used as an effective phase modulation method.
Journal ArticleDOI
Recruitment of tendon crimp with applied tensile strain.
TL;DR: This work used optical coherence tomography to determine how crimp period changed as a function of applied tensile strain in rat tail tendon fascicles, and showed a visual correspondence between features indicative of crimp pattern.
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Characterization of Outer Retinal Morphology with High-Speed, Ultrahigh-Resolution Optical Coherence Tomography
Vivek J. Srinivasan,B.K. Monson,Maciej Wojtkowski,Maciej Wojtkowski,Maciej Wojtkowski,Richard A. Bilonick,Iwona Gorczynska,Iwona Gorczynska,Royce W.S. Chen,Jay S. Duker,Joel S. Schuman,James G. Fujimoto +11 more
TL;DR: Quantitative maps of outer retinal layers showed clear differences between the cone-dominated fovea and the rod-dominated parafovea, indicating that photoreceptor morphology can explain the appearance of the outer retina in high-speed, UHR OCT images.
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Comparison between optical coherence tomography and fundus fluorescein angiography for the detection of cystoid macular edema in patients with uveitis.
Richard J. Antcliff,Miles Stanford,Devinder S. Chauhan,Elizabeth M. Graham,David J. Spalton,John S Shilling,T. J. Ffytche,John C. Marshall +7 more
TL;DR: In this paper, the authors compared OCT with fundus fluorescein angiography (FFA) for the detection of cystoid macular edema (CME) in patients with uveitis.
References
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Journal ArticleDOI
Computerized transverse axial scanning (tomography): Part I. Description of system. 1973.
TL;DR: A technique in which X-ray transmission readings are taken through the head at a multitude of angles: from these data, absorption values of the material contained within the head are calculated on a computer and presented as a series of pictures of slices of the cranium.
Journal ArticleDOI
Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss.
Alfred Sommer,Joanne Katz,Harry A. Quigley,Neil R. Miller,Alan L. Robin,Ronald C. Richter,Kathe A. Witt +6 more
TL;DR: Nerve fiber layer defects expanded with time, often by the development and coalescence of adjacent areas of damage, and field defects closely corresponded, but nerve fiber layer loss was generally more widespread.
Journal ArticleDOI
Theory and practice of scanning optical microscopy
Tony Wilson,Colin J. R. Sheppard +1 more
Journal ArticleDOI
Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma.
TL;DR: Estimates suggest that visual field sensitivity in automated testing begins to decline soon after the initial loss of ganglion cells in human eyes with glaucoma, and that this decline is most pronounced in areas that had 0-dB sensitivity in the field test.