Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Rapid-scanning forward-imaging miniature endoscope for real-time optical coherence tomography.
TL;DR: A miniature endoscope that is capable of rapid lateral scanning and is suitable for real-time forward-imaging optical coherence tomography (OCT) and operated in the new image acquisition sequence at 6 frames/s is demonstrated.
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Intra-retinal layer segmentation in optical coherence tomography images
TL;DR: Experimental results show that the proposed approach provides accurate segmentation for OCT images affected by speckle noise, even in sub-optimal conditions of low image contrast and presence of irregularly shaped structural features in the OCT images.
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Doppler optical micro-angiography for volumetric imaging of vascular perfusion in vivo
Ruikang K. Wang,Lin An +1 more
TL;DR: A Doppler optical micro-angiography method to image flow velocities of the blood flowing in functional vessels within microcirculatory tissue beds in vivo is proposed, and it is shown that DOMAG delivers at least 15-fold increase over the PRDOCT method in terms of the lower limit of flow velocity that can be detected.
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Simultaneous acquisition of sectional and fundus ophthalmic images with spectral-domain optical coherence tomography.
TL;DR: A fundus image similar to the intensity image produced by a scanning laser ophthalmoscope was generated from the same spectra that were used for generating the OCT sectional images immediately after the spectra were collected, which offers perfect spatial registration between the sectional OCT images and the fundu image.
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Gold nanoparticles in biological optical imaging
TL;DR: In this paper, the most recent achievements and challenges associated with using AuNPs to improve resolution and sensitivity in biological imaging in vitro and in vivo were discussed, including direct visualization of AuNs inside the biosystems using i) dark field (DF) microscopy, ii) differential interference contrast (DIC), and iii) other techniques, such as interferometric scattering microscopy and photothermal imaging.
References
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Journal ArticleDOI
Computerized transverse axial scanning (tomography): Part I. Description of system. 1973.
TL;DR: A technique in which X-ray transmission readings are taken through the head at a multitude of angles: from these data, absorption values of the material contained within the head are calculated on a computer and presented as a series of pictures of slices of the cranium.
Journal ArticleDOI
Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss.
Alfred Sommer,Joanne Katz,Harry A. Quigley,Neil R. Miller,Alan L. Robin,Ronald C. Richter,Kathe A. Witt +6 more
TL;DR: Nerve fiber layer defects expanded with time, often by the development and coalescence of adjacent areas of damage, and field defects closely corresponded, but nerve fiber layer loss was generally more widespread.
Journal ArticleDOI
Theory and practice of scanning optical microscopy
Tony Wilson,Colin J. R. Sheppard +1 more
Journal ArticleDOI
Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma.
TL;DR: Estimates suggest that visual field sensitivity in automated testing begins to decline soon after the initial loss of ganglion cells in human eyes with glaucoma, and that this decline is most pronounced in areas that had 0-dB sensitivity in the field test.