Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Journal ArticleDOI
Optical coherence tomography and microscopy in gastrointestinal tissues
TL;DR: Optical coherence tomography (OCT) and optical coherence microscopy (OCM) are novel techniques for noninvasive biomedical imaging based on low-coherence interferometry.
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Automatic segmentation of nine retinal layer boundaries in OCT images of non-exudative AMD patients using deep learning and graph search.
TL;DR: A novel framework combining convolutional neural networks (CNN) and graph search methods (termed as CNN-GS) for the automatic segmentation of nine layer boundaries on retinal optical coherence tomography (OCT) images is presented.
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Optical imaging in medicine: I. Experimental techniques.
TL;DR: The experimental techniques proposed in order to explore both direct and indirect imaging are reviewed, the relative merits and limitations of the various experimental methods are discussed, and the future directions and likelihood of success of optical imaging in medicine are considered.
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Quantitative OCT angiography of optic nerve head blood flow
Yali Jia,John C. Morrison,Jason Tokayer,Ou Tan,Lorinna Lombardi,Bernhard Baumann,Chen D. Lu,WooJhon Choi,James G. Fujimoto,David Huang +9 more
TL;DR: OCT angiography can detect the abnormalities of ONH perfusion and has the potential to reveal the ONH blood flow mechanism related to glaucoma, a pilot study indicates.
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Reproducibility of nerve fiber layer thickness measurements by use of optical coherence tomography
Eytan Z. Blumenthal,Julia M. Williams,Robert N. Weinreb,Christopher A. Girkin,Charles C. Berry,Linda M. Zangwill +5 more
TL;DR: The results indicate that the RNFL measurements are reproducible for both normal and glaucomatous eyes with the commercially available OCT 2000 instrument.
References
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