Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Retinal oxygen: from animals to humans
Robert A. Linsenmeier,Hao Zhang +1 more
TL;DR: Measurements made with two of the principal methods used to study O2 in the retina are discussed, focusing on measurements of PO2 with oxygen-sensitive microelectrodes in vivo in animals with a retinal circulation similar to that of humans, and oximetry, which can be used non-invasively in both animals and humans to measure O2 concentration in retinal vessels.
Journal ArticleDOI
Adaptive optics with a magnetic deformable mirror: applications in the human eye
Enrique J. Fernández,Laurent Vabre,Boris Hermann,Angelika Unterhuber,Boris Povazay,Wolfgang Drexler +5 more
TL;DR: Results from living eyes, including one exhibiting 4.66 D of myopia and a near pathologic cornea with notable high order aberrations, show a practically perfect aberration correction.
Journal ArticleDOI
Ultrahigh resolution optical coherence tomography and pancorrection for cellular imaging of the living human retina
Enrique J. Fernández,Boris Hermann,Boris Považay,Angelika Unterhuber,Harald Sattmann,Bernd Hofer,Peter K. Ahnelt,Wolfgang Drexler +7 more
TL;DR: The presented technique has the potential to unveil photoreceptor development and pathogenesis as well as improved therapy monitoring of numerous retinal diseases.
Journal Article
Macular Pigment and Lutein Supplementation in Retinitis Pigmentosa and Usher Syndrome
Tomas S. Aleman,Jacque L. Duncan,Michelle L. Bieber,Elaine de Castro,Daniel A. Marks,Leigh M. Gardner,Janet D. Steinberg,Artur V. Cideciyan,Maureen G. Maguire,Samuel G. Jacobson +9 more
TL;DR: There was no change in central vision after 6 months of lutein supplementation, but long-term influences on the natural history of these retinal degenerations require further study.
Journal ArticleDOI
High definition live 3D-OCT in vivo: design and evaluation of a 4D OCT engine with 1 GVoxel/s.
TL;DR: A 1300 nm OCT system for volumetric real-time live OCT acquisition and visualization at 1 billion volume elements per second is presented and potential future applications of such a system are evaluated.
References
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