Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TLDR
OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.Abstract:
A technique called optical coherence tomography (OCT) has been developed for noninvasive cross-sectional imaging in biological systems. OCT uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way that is analogous to ultrasonic pulse-echo imaging. OCT has longitudinal and lateral spatial resolutions of a few micrometers and can detect reflected signals as small as approximately 10(-10) of the incident optical power. Tomographic imaging is demonstrated in vitro in the peripapillary area of the retina and in the coronary artery, two clinically relevant examples that are representative of transparent and turbid media, respectively.read more
Citations
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Journal ArticleDOI
Redefining Lamellar Holes and the Vitreomacular Interface: An Ultrahigh-Resolution Optical Coherence Tomography Study
Andre J. Witkin,Tony H. Ko,James G. Fujimoto,Joel S. Schuman,Caroline R. Baumal,Adam H. Rogers,Elias Reichel,Jay S. Duker +7 more
TL;DR: The diagnosis of a lamellar hole can be made based on OCT criteria, which could be applied to both standard and ultrahigh-resolution OCT, and the increased resolution of UHR OCT sheds light on the pathogenesis of the lamellars hole.
Journal ArticleDOI
A comparison of retinal morphology viewed by optical coherence tomography and by light microscopy
Cynthia A. Toth,Drew G. Narayan,Stephen A. Boppart,M R Hee,James G. Fujimoto,Reginald Birngruber,Clarence P. Cain,C D DiCarlo,William P. Roach +8 more
TL;DR: Comparing cross-sectional images of primate retinal morphology obtained by optical coherence tomography with light microscopy to determine the retinal components represented in OCT images demonstrated reproducible patterns ofretinal morphology that corresponded to the location of retinal layers seen on light microscopic overlays.
Patent
Method and apparatus for tissue oximetry
TL;DR: In this article, the authors measured the oxygenation of blood-profused tissue by shining light into the profused tissue and analyzing the light reflected within the tissue, where the light is reflected by cell walls in the tissue and is partially absorbed by hemoglobin in the blood.
Journal ArticleDOI
Spectral-Domain Optical Coherence Tomography: A Comparison of Modern High-Resolution Retinal Imaging Systems
TL;DR: Advances in high-resolution imaging of the anterior and posterior segment have revealed new in vivo details of anatomic, physiologic, and pathologic data for the practice of ophthalmology, and as the technology develops, SD OCT will continue to provide new insights about ocular structure and disease.
Journal ArticleDOI
Ductal Carcinoma in Situ: State of the Science and Roadmap to Advance the Field
Henry Mark Kuerer,Constance Albarracin,Wei T. Yang,Robert D. Cardiff,Abenaa M. Brewster,W. Fraser Symmans,Nola M. Hylton,Lavinia P. Middleton,Savitri Krishnamurthy,George H. Perkins,Gildy Babiera,Mary E. Edgerton,Brian J. Czerniecki,Banu Arun,Gabriel N. Hortobagyi +14 more
TL;DR: There is a critical need for a concerted international effort among patients with DCIS, clinicians, and basic scientists to conduct the research necessary to improve fundamental understanding of the biology and clinical behavior of DCIS and prevent development of invasive breast cancer.
References
More filters
Journal ArticleDOI
Computerized transverse axial scanning (tomography): Part I. Description of system. 1973.
TL;DR: A technique in which X-ray transmission readings are taken through the head at a multitude of angles: from these data, absorption values of the material contained within the head are calculated on a computer and presented as a series of pictures of slices of the cranium.
Journal ArticleDOI
Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss.
Alfred Sommer,Joanne Katz,Harry A. Quigley,Neil R. Miller,Alan L. Robin,Ronald C. Richter,Kathe A. Witt +6 more
TL;DR: Nerve fiber layer defects expanded with time, often by the development and coalescence of adjacent areas of damage, and field defects closely corresponded, but nerve fiber layer loss was generally more widespread.
Journal ArticleDOI
Theory and practice of scanning optical microscopy
Tony Wilson,Colin J. R. Sheppard +1 more
Journal ArticleDOI
Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma.
TL;DR: Estimates suggest that visual field sensitivity in automated testing begins to decline soon after the initial loss of ganglion cells in human eyes with glaucoma, and that this decline is most pronounced in areas that had 0-dB sensitivity in the field test.